### CLUSTER 1 ### 01 Metabolism SWH1 01 OSH2 steroid biosynthesis; plasma membrane; bud neck; 01 ### CLUSTER 2 ### 08 Cellular transport YPL071C UFE1 retrograde (Golgi to ER) transport; nonselective vesicle fusion; endoplasmic reticulum membrane; 14 08 ARL3 intracellular protein transport; soluble fraction; nuclear envelope-endoplasmic reticulum network; 08 06 ### CLUSTER 3 ### 03 Cell cycle & DNA processing MCM2 pre-replicative complex formation and maintenance; DNA unwinding; DNA replication initiation; nucleus; pre-replicative complex; cytoplasm; 03 MCM3 pre-replicative complex formation and maintenance; DNA unwinding; DNA replication initiation; nucleus; pre-replicative complex; cytoplasm; 03 CDC47 pre-replicative complex formation and maintenance; DNA unwinding; DNA replication initiation; nucleus; pre-replicative complex; cytoplasm; 03 MCM10 DNA replication initiation; DNA strand elongation; nucleus; 03 CDC46 pre-replicative complex formation and maintenance; DNA unwinding; DNA replication initiation; establishment of chromatin silencing; pre-replicative complex; replication fork; cytoplasm; 03 ### CLUSTER 4 ### 00 Not clear PET127 RNA processing; mitochondrial membrane; 05 ECI1 fatty acid beta-oxidation; peroxisome; 01 02 ### CLUSTER 5 ### 00 Not clear COS111 signal transduction; 10 YFL042C VID30 regulation of nitrogen utilization; negative regulation of gluconeogenesis; 06 MTO1 protein biosynthesis; mitochondrion; 05 YER080W RIM8 invasive growth; meiosis; protein processing; ESC2 chromatin silencing at HML and HMR (sensu Saccharomyces); nucleus; 04 ### CLUSTER 6 ### 00 Not clear YPL113C metabolism; 01 MCH5 transport; membrane; YGL185C metabolism; YOR390W PHO91 phosphate transport; membrane; 01 13 YKR106W transport; membrane; 11 YIL057C MUP3 amino acid transport; membrane; 01 08 DAN4 cell wall (sensu Fungi); YNL129W YEL070W 01 ### CLUSTER 7 ### 06 Protein fate YDR316W ULA1 protein neddylation; 06 ### CLUSTER 8 ### 01 Metabolism YPL088W aldehyde metabolism; 02 01 SPR1 sporulation (sensu Saccharomyces); cell wall (sensu Fungi); 14 01 YPL264C integral to membrane; DDC1 cell cycle checkpoint; meiosis; condensed nuclear chromosome; 03 11 FDH1 NADH regeneration; formate catabolism; cytosol; 02 ### CLUSTER 9 ### 03 Cell cycle & DNA processing RAD52 meiotic DNA recombinase assembly; telomerase-independent telomere maintenance; double-strand break repair via break-induced replication; DNA recombinase assembly; double-strand break repair via single-strand annealing; double-strand break repair via synthesis-dependent strand annealing; nuclear chromosome; nucleus; 03 14 RAD14 nucleotide-excision repair\, DNA damage recognition; nucleotide excision repair factor 1 complex; 03 RAD10 removal of nonhomologous ends; double-strand break repair via single-strand annealing\, removal of nonhomologous ends; nucleotide-excision repair\, DNA incision\, 5' to lesion; nucleotide excision repair factor 1 complex; 03 REV1 DNA dependent DNA replication; DNA repair; nucleus; 03 YAL027W DED1 translational initiation; cytoplasm; 04 05 MSH2 removal of nonhomologous ends; mismatch repair; DNA recombination; mitotic recombination; nuclear chromosome; 03 RAD26 transcription-coupled nucleotide-excision repair; nucleotide-excision repair; nucleus; 03 SSL2 nucleotide-excision repair\, DNA duplex unwinding; transcription initiation from Pol II promoter; negative regulation of transcription from Pol II promoter\, mitotic; nucleotide excision repair factor 3 complex; transcription factor TFIIH complex; 03 04 RAD7 nucleotide-excision repair\, DNA damage recognition; repairosome; nucleotide excision repair factor 4 complex; 03 RAD4 nucleotide-excision repair\, DNA damage recognition; repairosome; nucleotide excision repair factor 2 complex; 03 RAD16 nucleotide-excision repair\, DNA damage recognition; repairosome; nucleotide excision repair factor 4 complex; 03 RAD3 nucleotide-excision repair\, DNA duplex unwinding; transcription initiation from Pol II promoter; negative regulation of transcription from Pol II promoter\, mitotic; nucleotide excision repair factor 3 complex; transcription factor TFIIH complex; 04 03 RAD2 nucleotide-excision repair\, DNA incision\, 3' to lesion; nucleotide excision repair factor 3 complex; 03 ### CLUSTER 10 ### 03 Cell cycle & DNA processing XRS2 double-strand break repair via break-induced replication; double-strand break repair via nonhomologous end-joining; meiotic DNA double-strand break formation; nucleus; 03 RAD59 telomerase-independent telomere maintenance; double-strand break repair via break-induced replication; double-strand break repair via single-strand annealing; nucleus; 03 RAD57 meiotic DNA recombinase assembly; telomerase-independent telomere maintenance; double-strand break repair via break-induced replication; DNA recombinase assembly; double-strand break repair via single-strand annealing; double-strand break repair via synthesis-dependent strand annealing; nucleus; 14 03 RAD55 meiotic DNA recombinase assembly; double-strand break repair via break-induced replication; DNA recombinase assembly; double-strand break repair via single-strand annealing; double-strand break repair via synthesis-dependent strand annealing; nucleus; 03 14 RAD51 meiotic joint molecule formation; telomerase-independent telomere maintenance; double-strand break repair via break-induced replication; chromatin modeling; heteroduplex formation; strand invasion; double-strand break repair via single-strand annealing; double-strand break repair via synthesis-dependent strand annealing; nuclear chromosome; condensed nuclear chromosome; 14 03 RAD54 telomerase-independent telomere maintenance; double-strand break repair via break-induced replication; chromatin modeling; heteroduplex formation; double-strand break repair via single-strand annealing; double-strand break repair via synthesis-dependent strand annealing; nucleus; 03 ### CLUSTER 11 ### 03 Cell cycle & DNA processing RFA3 DNA unwinding; DNA replication\, priming; DNA strand elongation; nucleotide-excision repair; postreplication repair; double-strand break repair; DNA recombination; DNA replication factor A complex; 03 RFA1 DNA unwinding; DNA replication\, priming; DNA strand elongation; nucleotide-excision repair; postreplication repair; double-strand break repair; DNA recombination; DNA replication factor A complex; 14 03 ### CLUSTER 12 ### 03 Cell cycle & DNA processing MLH2 DNA repair; nucleus; 03 MSH5 meiotic recombination; nucleus; 03 MSH4 meiotic recombination; nuclear chromosome; 03 MSH1 DNA repair; mitochondrion; 03 MSH6 mismatch repair; nucleus; 03 MLH1 meiotic recombination; nucleus; 03 POL30 leading strand elongation; lagging strand elongation; mutagenesis; base-excision repair; nucleotide-excision repair; mismatch repair; postreplication repair; replication fork; 03 ### CLUSTER 13 ### 00 Not clear SMA2 spore wall assembly (sensu Saccharomyces); PMS1 mismatch repair; meiosis; nuclear chromosome; 03 ESC8 chromatin silencing; nucleus; ### CLUSTER 14 ### 03 Cell cycle & DNA processing RAD9 regulation of cell cycle; DNA damage response\, signal transduction resulting in cell cycle arrest; DNA repair; nucleotide-excision repair; positive regulation of transcription from Pol II promoter; nucleus; 03 04 TEL1 response to DNA damage stimulus; telomerase-dependent telomere maintenance; nucleus; 01 03 MEC1 DNA replication checkpoint; DNA damage response\, signal transduction resulting in cell cycle arrest; nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism; DNA recombination; meiotic recombination; nucleus; 03 DUN1 cell cycle checkpoint; DNA damage response\, signal transduction resulting in cell cycle arrest; protein amino acid phosphorylation; 10 03 DBF4 DNA replication initiation; regulation of DNA replication; protein amino acid phosphorylation; nucleoplasm; 03 PTC2 DNA damage response\, signal transduction resulting in cell cycle arrest; regulation of CDK activity; G1/S transition of mitotic cell cycle; inactivation of MAPK (osmolarity sensing); protein amino acid dephosphorylation; response to unfolded protein; ASF1 DNA damage response\, signal transduction resulting in induction of apoptosis; chromatin assembly complex; 04 RAD50 meiotic DNA double-strand break processing; telomerase-independent telomere maintenance; double-strand break repair via break-induced replication; double-strand break repair via nonhomologous end-joining; meiotic DNA double-strand break formation; nucleus; 03 RAD17 DNA damage response\, signal transduction resulting in cell cycle arrest; meiotic recombination; nucleus; 03 MEC3 DNA damage response\, signal transduction resulting in cell cycle arrest; DNA metabolism; chromatin silencing at telomere; nucleus; 03 RAD24 DNA damage response\, signal transduction resulting in cell cycle arrest; nucleotide-excision repair; meiotic recombination; nucleus; 03 ### CLUSTER 15 ### 03 Cell cycle & DNA processing POL2 DNA repair synthesis; leading strand elongation; lagging strand elongation; nucleotide-excision repair; mismatch repair; replication fork; 03 PRI2 DNA repair synthesis; DNA replication\, priming; DNA replication initiation; lagging strand elongation; alpha DNA polymerase\:primase complex; 03 DPB11 DNA replication initiation; leading strand elongation; lagging strand elongation; nucleotide-excision repair; mismatch repair; replication fork; 03 DPB4 leading strand elongation; lagging strand elongation; epsilon DNA polymerase complex; 04 CTF18 sister chromatid cohesion; DNA replication factor C complex; 03 DPB3 leading strand elongation; lagging strand elongation; nucleotide-excision repair; mismatch repair; replication fork; 03 REV3 mutagenesis; DNA repair; nucleus; 03 PSD1 phosphatidylcholine biosynthesis; mitochondrion; mitochondrial inner membrane; 01 TAT2 aromatic amino acid transport; plasma membrane; 08 01 ### CLUSTER 16 ### 03 Cell cycle & DNA processing POL32 leading strand elongation; lagging strand elongation; mutagenesis; base-excision repair; nucleotide-excision repair; mismatch repair; postreplication repair; nucleus; delta DNA polymerase complex; 03 PRI1 DNA replication\, priming; DNA replication initiation; lagging strand elongation; alpha DNA polymerase\:primase complex; 03 POL12 DNA replication\, priming; DNA replication initiation; lagging strand elongation; alpha DNA polymerase\:primase complex; 03 ### CLUSTER 17 ### 00 Not clear YBR070C 11 DNA2 DNA dependent DNA replication; lagging strand elongation; DNA repair; nucleus; 03 ### CLUSTER 18 ### 00 Not clear STN1 telomere capping; nuclear telomere cap complex; 03 RPR2 tRNA processing; nucleolar ribonuclease P complex; 04 ### CLUSTER 19 ### 03 Cell cycle & DNA processing YDR540C SCC2 mitotic sister chromatid cohesion; nuclear cohesin complex; 03 ### CLUSTER 20 ### 03 Cell cycle & DNA processing SMC1 mitotic chromosome segregation; nuclear cohesin complex; 03 IRR1 cytogamy; mitotic sister chromatid cohesion; colony morphology; germination (sensu Saccharomyces); nuclear cohesin complex; 03 14 SMC2 mitotic chromosome segregation; mitotic chromosome condensation; nuclear condensin complex; 03 ### CLUSTER 21 ### 03 Cell cycle & DNA processing RAX2 bud site selection; bud scar; bud neck; membrane; ECO1 DNA replication; DNA repair; sister chromatid cohesion; nuclear chromatin; 03 ### CLUSTER 22 ### 03 Cell cycle & DNA processing RFC5 leading strand elongation; mismatch repair; sister chromatid cohesion; DNA replication factor C complex; 03 CTF8 sister chromatid cohesion; DNA replication factor C complex; RFC3 leading strand elongation; mismatch repair; sister chromatid cohesion; nucleus; DNA replication factor C complex; 03 RFC2 cell cycle checkpoint; leading strand elongation; mismatch repair; sister chromatid cohesion; DNA replication factor C complex; 03 ### CLUSTER 23 ### 00 Not clear YJL160C 14 11 SAE3 meiotic recombination; 03 GOD1 ARP7 chromatin modeling; nucleus; nucleosome remodeling complex; SWI/SNF complex; ### CLUSTER 24 ### 03 Cell cycle & DNA processing ZIP1 meiosis; synapsis; synaptonemal complex; 03 SPO11 meiotic DNA double-strand break formation; nuclear chromosome; 03 MEI4 meiotic recombination; sporulation (sensu Fungi); meiotic DNA double-strand break formation; 14 03 SPO13 positive regulation of sister chromatid cohesion; nucleus; 03 REC104 meiotic recombination; meiotic DNA double-strand break formation; 03 REC107 meiotic recombination; 03 HOP1 meiosis; synaptonemal complex formation; condensed nuclear chromosome; synaptonemal complex; 03 RED1 synaptonemal complex formation; synaptonemal complex; 03 ### CLUSTER 25 ### 00 Not clear YGR131W 08 MIG3 transcription initiation; nucleus; 04 YBL029W SAG1 agglutination during conjugation with cellular fusion; cell wall (sensu Fungi); 14 ASP3-3 asparagine catabolism; cellular response to nitrogen starvation; periplasmic space (sensu Fungi); 01 YIL166C transport; membrane; QDR1 multidrug transport; plasma membrane; integral to plasma membrane; 11 REC102 meiotic recombination; meiotic DNA double-strand break formation; nucleus; 03 ### CLUSTER 26 ### 01 Metabolism SSK2 activation of MAPKK (osmolarity sensing); protein amino acid phosphorylation; osmosensory signaling pathway; actin cytoskeleton organization and biogenesis; cytosol; 11 13 HES1 steroid biosynthesis; 01 INP52 endocytosis; cell wall organization and biogenesis; dephosphorylation; membrane fraction; actin cortical patch (sensu Saccharomyces); 01 RAS1 G-protein signaling\, adenylate cyclase activating pathway; RAS protein signal transduction; cell proliferation; plasma membrane; 01 14 13 03 10 MER1 meiosis; nucleus; 03 04 ### CLUSTER 27 ### 03 Cell cycle & DNA processing YKU70 telomere maintenance; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end-joining; chromatin assembly/disassembly; transcriptional gene silencing; nuclear chromatin; nuclear membrane; nuclear telomeric heterochromatin; 03 YKU80 telomere maintenance; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end-joining; chromatin assembly/disassembly; transcriptional gene silencing; nuclear chromatin; nuclear telomeric heterochromatin; 03 MRE11 meiotic DNA double-strand break processing; double-strand break repair via break-induced replication; DNA repair; double-strand break repair via nonhomologous end-joining; meiotic DNA double-strand break formation; nucleus; 03 ### CLUSTER 28 ### 01 Metabolism ARO8 aromatic amino acid family metabolism; 01 ARO10 leucine catabolism; phenylalanine catabolism; 01 02 ### CLUSTER 29 ### 01 Metabolism NPY1 NADH metabolism; cytoplasm; peroxisome; 01 ALG2 oligosaccharide-lipid intermediate assembly; endoplasmic reticulum; 06 01 ### CLUSTER 30 ### 14 Cell fate YGL015C PEA2 establishment of cell polarity (sensu Saccharomyces); actin filament organization; polar budding; Rho protein signal transduction; polarisome; actin cap (sensu Saccharomyces); 14 ### CLUSTER 31 ### 14 Cell fate MKK1 protein amino acid phosphorylation; signal transduction; bud tip; 14 03 11 BUL1 mitochondrion inheritance; protein polyubiquitination; protein monoubiquitination; plasma membrane; 06 SLT2 protein amino acid phosphorylation; cell wall organization and biogenesis; signal transduction; nucleus; cytoplasm; bud tip; 14 11 13 03 SPH1 establishment of cell polarity (sensu Saccharomyces); actin filament organization; polar budding; pseudohyphal growth; Rho protein signal transduction; incipient bud site; polarisome; bud tip; bud neck; shmoo tip; 14 SPA2 establishment of cell polarity (sensu Saccharomyces); actin filament organization; polar budding; pseudohyphal growth; Rho protein signal transduction; incipient bud site; polarisome; bud tip; bud neck; shmoo tip; 14 13 BCK1 establishment of cell polarity (sensu Saccharomyces); protein amino acid phosphorylation; protein kinase cascade; response to nutrients; intracellular; 14 11 03 ### CLUSTER 32 ### 01 Metabolism SSN3 negative regulation of transcription from Pol II promoter; protein amino acid phosphorylation; meiosis; regulation of transcription; transcription factor complex; 01 04 03 RDR1 response to xenobiotic stimulus; nucleus; MEK1 protein amino acid phosphorylation; meiosis; nucleus; 03 GRE2 response to stress; nucleus; cytoplasm; 01 ### CLUSTER 33 ### 14 Cell fate BNR1 response to osmotic stress; actin filament organization; axial budding; contractile ring (sensu Saccharomyces); 14 HOF1 cytokinesis; contractile ring (sensu Saccharomyces); 03 14 BUD6 bud site selection; establishment of cell polarity (sensu Saccharomyces); cytokinesis; response to osmotic stress; actin filament organization; polar budding; Rho protein signal transduction; polarisome; actin cap (sensu Saccharomyces); 14 ### CLUSTER 34 ### 14 Cell fate DBR1 RNA catabolism; snoRNA metabolism; nucleus; 14 01 BUD8 bud site selection; pseudohyphal growth; incipient bud site; bud tip; 14 DFG10 pseudohyphal growth; 14 ### CLUSTER 35 ### 06 Protein fate TVP18 APC1 mitotic spindle elongation; mitotic chromosome segregation; ubiquitin-dependent protein catabolism; mitotic metaphase/anaphase transition; cyclin catabolism; anaphase-promoting complex; 03 06 ALG8 dolichol-linked oligosaccharide biosynthesis; oligosaccharide-lipid intermediate assembly; endoplasmic reticulum membrane; 01 06 YMR299C APC2 mitotic spindle elongation; mitotic chromosome segregation; ubiquitin-dependent protein catabolism; mitotic metaphase/anaphase transition; cyclin catabolism; anaphase-promoting complex; 03 06 ### CLUSTER 36 ### 03 Cell cycle & DNA processing DOC1 mitotic spindle elongation; mitotic chromosome segregation; ubiquitin-dependent protein catabolism; mitotic metaphase/anaphase transition; cyclin catabolism; anaphase-promoting complex; 03 06 CDC26 mitotic spindle elongation; mitotic chromosome segregation; ubiquitin-dependent protein catabolism; mitotic metaphase/anaphase transition; cyclin catabolism; anaphase-promoting complex; 06 03 CDC27 mitotic spindle elongation; mitotic chromosome segregation; ubiquitin-dependent protein catabolism; mitotic metaphase/anaphase transition; cyclin catabolism; anaphase-promoting complex; 03 06 APC11 mitotic spindle elongation; mitotic chromosome segregation; ubiquitin-dependent protein catabolism; mitotic metaphase/anaphase transition; cyclin catabolism; anaphase-promoting complex; 03 06 APC4 mitotic spindle elongation; mitotic chromosome segregation; ubiquitin-dependent protein catabolism; mitotic metaphase/anaphase transition; cyclin catabolism; anaphase-promoting complex; 03 06 CDC16 mitotic spindle elongation; mitotic chromosome segregation; ubiquitin-dependent protein catabolism; mitotic metaphase/anaphase transition; cyclin catabolism; anaphase-promoting complex; 03 06 APC9 mitotic spindle elongation; mitotic chromosome segregation; ubiquitin-dependent protein catabolism; mitotic metaphase/anaphase transition; cyclin catabolism; anaphase-promoting complex; 03 06 CDC23 mitotic spindle elongation; mitotic chromosome segregation; ubiquitin-dependent protein catabolism; mitotic metaphase/anaphase transition; cyclin catabolism; anaphase-promoting complex; 03 06 ### CLUSTER 37 ### 03 Cell cycle & DNA processing MAD1 nucleocytoplasmic transport; mitotic spindle checkpoint; nucleus; nuclear pore; 03 YIL023C Q0092 MAD3 mitotic spindle checkpoint; nucleus; 03 BUB1 protein amino acid phosphorylation; mitotic spindle checkpoint; kinetochore; condensed nuclear chromosome kinetochore; nucleus; 03 ### CLUSTER 38 ### 00 Not clear CDC7 DNA replication initiation; regulation of DNA replication; protein amino acid phosphorylation; nucleoplasm; 03 AMA1 meiosis I; sporulation (sensu Saccharomyces); protein catabolism; anaphase-promoting complex; 14 ### CLUSTER 39 ### 03 Cell cycle & DNA processing CDC15 cytokinesis; protein amino acid phosphorylation; regulation of exit from mitosis; spindle pole body; bud neck; 03 CDC14 protein amino acid dephosphorylation; regulation of exit from mitosis; nucleus; nucleolus; spindle pole body; 03 BFA1 conjugation with cellular fusion; mitotic spindle checkpoint; spindle pole body; 03 ### CLUSTER 40 ### 00 Not clear DEM1 CDC3 establishment of cell polarity (sensu Saccharomyces); cellular morphogenesis; cytokinesis; cell wall organization and biogenesis; axial budding; septin ring (sensu Saccharomyces); spore wall (sensu Fungi); prospore membrane; shmoo tip; 14 03 ADE13 purine base metabolism; 01 ### CLUSTER 41 ### 03 Cell cycle & DNA processing SIZ1 protein sumoylation; septin ring; 06 SHS1 establishment of cell polarity (sensu Saccharomyces); cellular morphogenesis; cytokinesis; septin ring; 14 03 CDC10 establishment of cell polarity (sensu Saccharomyces); conjugation with cellular fusion; cellular morphogenesis during conjugation with cellular fusion; cellular morphogenesis; cytokinesis; cell wall organization and biogenesis; axial budding; polar budding; spore wall assembly (sensu Saccharomyces); septin ring (sensu Saccharomyces); 01 03 14 CDC12 establishment of cell polarity (sensu Saccharomyces); conjugation with cellular fusion; cellular morphogenesis; cytokinesis; cell wall organization and biogenesis; axial budding; polar budding; septin ring (sensu Saccharomyces); cytoplasm; 14 03 01 KCC4 septin checkpoint; septin ring assembly; protein amino acid phosphorylation; bud growth; axial budding; bud neck; 03 GIN4 septin checkpoint; septin ring assembly; protein amino acid phosphorylation; bud growth; axial budding; bud neck; 14 03 CDC8 dTDP biosynthesis; dTTP biosynthesis; DNA dependent DNA replication; plasmid maintenance; mutagenesis; DNA repair; nucleus; cytoplasm; 01 HSL1 regulation of cell cycle; cell morphogenesis checkpoint; G2/M transition of mitotic cell cycle; septin checkpoint; protein amino acid phosphorylation; bud neck; septin ring; 03 14 CDC11 establishment of cell polarity (sensu Saccharomyces); conjugation with cellular fusion; cellular morphogenesis; cytokinesis; cell wall organization and biogenesis; axial budding; septin ring (sensu Saccharomyces); spore wall (sensu Fungi); prospore membrane; shmoo tip; 14 03 01 ### CLUSTER 42 ### 01 Metabolism ROT2 cell wall biosynthesis (sensu Fungi); endoplasmic reticulum; 02 01 RAM1 protein amino acid farnesylation; protein farnesyltransferase complex; 06 01 10 CDC43 establishment of cell polarity (sensu Saccharomyces); calcium ion homeostasis; small GTPase mediated signal transduction; protein amino acid geranylgeranylation; intracellular; 01 06 03 14 STE14 peptide pheromone maturation; endoplasmic reticulum membrane; 01 06 ### CLUSTER 43 ### 00 Not clear RAM2 peptide pheromone maturation; protein amino acid farnesylation; protein amino acid geranylgeranylation; protein farnesyltransferase complex; 06 01 MAD2 mitotic spindle checkpoint; condensed nuclear chromosome kinetochore; nuclear pore; 03 ### CLUSTER 44 ### 14 Cell fate MSB2 establishment of cell polarity (sensu Saccharomyces); response to osmotic stress; integral to plasma membrane; 14 BUD4 bud site selection; axial budding; contractile ring (sensu Saccharomyces); 14 ### CLUSTER 45 ### 14 Cell fate BUD5 bud site selection; axial budding; polar budding; pseudohyphal growth; small GTPase mediated signal transduction; incipient bud site; bud neck; 14 BUD3 bud site selection; cytokinesis; axial budding; contractile ring (sensu Saccharomyces); 14 ### CLUSTER 46 ### 14 Cell fate BOI1 establishment of cell polarity (sensu Saccharomyces); Rho protein signal transduction; site of polarized growth (sensu Saccharomyces); bud; bud neck; 14 CDC24 establishment of cell polarity (sensu Saccharomyces); signal transduction during conjugation with cellular fusion; cellular morphogenesis during conjugation with cellular fusion; chitin localization; apical bud growth; isotropic bud growth; pseudohyphal growth; invasive growth; small GTPase mediated signal transduction; incipient bud site; nucleus; bud neck; shmoo tip; 14 03 13 BEM1 establishment of cell polarity (sensu Saccharomyces); cellular morphogenesis during conjugation with cellular fusion; incipient bud site; bud tip; bud neck; 14 03 RDI1 actin filament organization; small GTPase mediated signal transduction; cytosol; 14 BEM2 microtubule cytoskeleton organization and biogenesis; establishment of cell polarity (sensu Saccharomyces); cell wall organization and biogenesis; bud growth; small GTPase mediated signal transduction; actin cytoskeleton organization and biogenesis; intracellular; 14 03 GIC1 establishment of cell polarity (sensu Saccharomyces); axial budding; Rho protein signal transduction; incipient bud site; actin cap (sensu Saccharomyces); bud tip; bud neck; 13 14 BUD2 bud site selection; axial budding; polar budding; small GTPase mediated signal transduction; intracellular; 14 GIC2 establishment of cell polarity (sensu Saccharomyces); axial budding; Rho protein signal transduction; incipient bud site; actin cap (sensu Saccharomyces); bud tip; shmoo tip; 14 13 STE20 bud site selection; signal transduction during conjugation with cellular fusion; protein amino acid phosphorylation; pseudohyphal growth; incipient bud site; shmoo tip; 13 14 ### CLUSTER 47 ### 00 Not clear YDR319C MPT5 mRNA catabolism\, deadenylation-dependent; re-entry into mitotic cell cycle after pheromone arrest; loss of chromatin silencing during replicative cell aging; protein targeting; cell wall organization and biogenesis; 03 14 13 11 ### CLUSTER 48 ### 00 Not clear YDL186W YDL180W ### CLUSTER 49 ### 13 Regulation/Integration with environment STE3 signal transduction during conjugation with cellular fusion; integral to plasma membrane; 10 13 14 PLP1 positive regulation of transcription from Pol II promoter by pheromones; cytoplasm; 13 FUS1 conjugation with cellular fusion; plasma membrane; shmoo tip; 14 13 STE7 signal transduction during conjugation with cellular fusion; protein amino acid phosphorylation; pseudohyphal growth; cytoplasm; shmoo tip; 14 13 STE5 signal transduction during conjugation with cellular fusion; nucleus; cytoplasm; plasma membrane; shmoo tip; 13 14 FUS3 signal transduction during conjugation with cellular fusion; protein amino acid phosphorylation; cell cycle arrest; nucleus; cytoplasm; shmoo tip; 13 03 14 STE12 conjugation with cellular fusion; pseudohyphal growth; invasive growth; positive regulation of transcription from Pol II promoter by pheromones; nucleus; 14 13 04 STE2 response to pheromone during conjugation with cellular fusion; formation of a cell surface projection; integral to plasma membrane; 14 13 10 GPA1 signal transduction during conjugation with cellular fusion; heterotrimeric G-protein complex; plasma membrane; 14 10 13 KSS1 signal transduction during conjugation with cellular fusion; protein amino acid phosphorylation; cell cycle arrest; pseudohyphal growth; nucleus; 14 13 STE18 signal transduction during conjugation with cellular fusion; cytoplasm; heterotrimeric G-protein complex; plasma membrane; 10 13 14 AKR1 signal transduction during conjugation with cellular fusion; endocytosis; protein amino acid palmitoylation; membrane; 13 14 STE50 MAPKKK cascade (osmolarity sensing); MAPKKK cascade (pseudohyphal growth); signal transduction during conjugation with cellular fusion; response to pheromone; cytoplasm; 13 14 ### CLUSTER 50 ### 14 Cell fate YDR415C 06 TEC1 pseudohyphal growth; positive regulation of transcription from Pol II promoter; nucleus; 14 04 DIG2 invasive growth; nucleus; 14 ### CLUSTER 51 ### 01 Metabolism SKP1 G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; ubiquitin-dependent protein catabolism; nuclear ubiquitin ligase complex; kinetochore; nucleus; cytoplasm; SCF ubiquitin ligase complex; 01 06 03 CDC53 G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; ubiquitin-dependent protein catabolism; nuclear ubiquitin ligase complex; SCF ubiquitin ligase complex; 01 06 03 CDC34 G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; ubiquitin-dependent protein catabolism; nuclear ubiquitin ligase complex; nucleus; cytoplasm; 01 06 03 YIL001W ### CLUSTER 52 ### 14 Cell fate YOL007C 01 IPT1 mannosyl diphosphorylinositol ceramide metabolism; membrane fraction; 01 YNL300W cell wall (sensu Fungi); AXL2 bud site selection; axial budding; integral to plasma membrane; bud; bud neck; septin ring; 14 FAR1 signal transduction during conjugation with cellular fusion; cell cycle arrest; nucleus; cytoplasm; 14 13 03 SWI6 G1/S-specific transcription in mitotic cell cycle; transcription; meiosis; nucleus; cytoplasm; 03 04 GRR1 G1/S transition of mitotic cell cycle; ubiquitin-dependent protein catabolism; contractile ring (sensu Saccharomyces); nuclear ubiquitin ligase complex; nucleus; cytoplasm; 01 14 03 08 11 PHO85 glycogen metabolism; protein amino acid phosphorylation; phosphate metabolism; cell cycle; nucleus; 01 04 03 02 DIG1 invasive growth; nucleus; 14 YOL019W STE4 signal transduction during conjugation with cellular fusion; heterotrimeric G-protein complex; plasma membrane; shmoo tip; 14 13 10 SVS1 response to chemical substance; 11 MSG5 adaptation to pheromone during conjugation with cellular fusion; 03 05 13 14 TOS2 bud tip; bud neck; 14 ### CLUSTER 53 ### 03 Cell cycle & DNA processing SWI5 G1-specific transcription in mitotic cell cycle; nucleus; cytoplasm; 14 04 MUS81 DNA repair; meiotic recombination; nucleus; 03 ESP1 regulation of exit from mitosis; mitotic sister chromatid separation; nucleus; cytoplasm; spindle; 03 MIH1 regulation of CDK activity; G2/M transition of mitotic cell cycle; 03 FPR1 06 TEM1 M phase of mitotic cell cycle; signal transduction; spindle pole body; 03 10 RAD53 nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism; DNA repair; nucleus; 10 03 IPL1 chromosome segregation; kinetochore microtubule; spindle microtubule; 03 PHM6 YHL029C CLN2 regulation of CDK activity; re-entry into mitotic cell cycle after pheromone arrest; nucleus; cytoplasm; 03 14 YPL267W CLB2 regulation of CDK activity; G2/M transition of mitotic cell cycle; nucleus; cytoplasm; 14 03 YPL141C MRPL50 protein biosynthesis; mitochondrial large ribosomal subunit; 05 CLB4 regulation of CDK activity; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; 03 UBI4 protein polyubiquitination; protein monoubiquitination; response to stress; sporulation (sensu Saccharomyces); protein deubiquitination; cytoplasm; 05 11 06 14 NAP1 M phase of mitotic cell cycle; nucleosome assembly; nucleus; 03 14 06 SWE1 cell morphogenesis checkpoint; regulation of CDK activity; G2/M transition of mitotic cell cycle; regulation of meiosis; nucleus; bud neck; 03 14 CDC5 DNA dependent DNA replication; protein amino acid phosphorylation; spindle pole; nucleus; bud neck; 03 CDH1 mitotic spindle elongation; mitotic chromosome segregation; ubiquitin-dependent protein catabolism; mitotic metaphase/anaphase transition; cyclin catabolism; regulation of cell size; nucleus; anaphase-promoting complex; cytoplasm; 03 06 CDC20 mitotic spindle elongation; mitotic chromosome segregation; ubiquitin-dependent protein catabolism; mitotic metaphase/anaphase transition; cyclin catabolism; anaphase-promoting complex; 06 03 ACE2 G1-specific transcription in mitotic cell cycle; nucleus; cytosol; 01 03 04 ALK1 mitosis; nucleus; 11 SIC1 regulation of CDK activity; G1/S transition of mitotic cell cycle; nucleus; cytoplasm; 03 SWI4 G1/S transition of mitotic cell cycle; transcription; cell cycle; nucleus; 03 04 CLB3 regulation of CDK activity; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; 03 CLB1 mitotic spindle assembly (sensu Saccharomyces); regulation of CDK activity; G2/M transition of mitotic cell cycle; meiotic G2/MI transition; 03 CLB6 regulation of CDK activity; G1/S transition of mitotic cell cycle; premeiotic DNA synthesis; 03 CKS1 regulation of cell cycle; 03 CDC28 regulation of cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; G2/M transition of mitotic cell cycle; protein amino acid phosphorylation; regulation of meiosis; nucleus; cytoplasm; 14 03 CLN3 regulation of CDK activity; G1/S transition of mitotic cell cycle; nucleus; 14 11 03 ### CLUSTER 54 ### 03 Cell cycle & DNA processing YCR015C PDS1 protein-nucleus import; mitotic sister chromatid separation; nucleus; spindle; 03 ### CLUSTER 55 ### 01 Metabolism PHO4 phosphate metabolism; cellular response to phosphate starvation; nucleus; cytoplasm; 01 04 PCL9 cell cycle; cyclin-dependent protein kinase holoenzyme complex; PHO80 regulation of phosphate metabolism; cyclin-dependent protein kinase holoenzyme complex; 01 04 PCL1 cell cycle; cyclin-dependent protein kinase holoenzyme complex; 03 PCL2 cell cycle; cyclin-dependent protein kinase holoenzyme complex; 03 YMR222C 01 YLR137W ARK1 actin cortical patch assembly; cytokinesis; protein amino acid phosphorylation; actin filament organization; actin cortical patch (sensu Saccharomyces); PCL10 regulation of glycogen biosynthesis; regulation of glycogen catabolism; cyclin-dependent protein kinase holoenzyme complex; 01 02 PCL6 regulation of glycogen biosynthesis; regulation of glycogen catabolism; cyclin-dependent protein kinase holoenzyme complex; CLG1 cell cycle; cyclin-dependent protein kinase holoenzyme complex; 03 PHO81 phosphate metabolism; 01 PCL5 cell cycle; cyclin-dependent protein kinase holoenzyme complex; STP4 04 01 PCL7 regulation of glycogen biosynthesis; regulation of glycogen catabolism; cyclin-dependent protein kinase holoenzyme complex; CLN1 regulation of CDK activity; nucleus; cytoplasm; 03 PHO5 phosphate metabolism; cellular response to phosphate starvation; cell wall (sensu Fungi); periplasmic space (sensu Fungi); 01 ### CLUSTER 56 ### 01 Metabolism SPE4 spermine biosynthesis; pantothenate biosynthesis; 01 DCS2 ### CLUSTER 57 ### 00 Not clear LYS1 lysine biosynthesis\, aminoadipic pathway; cytoplasm; peroxisome; 01 YDR140W 06 TRM9 ### CLUSTER 58 ### 01 Metabolism CCP1 response to oxidative stress; mitochondrion; mitochondrial intermembrane space; 11 NCR1 01 MET2 methionine biosynthesis; homoserine metabolism; cytoplasm; 01 DIT1 spore wall assembly (sensu Saccharomyces); 14 CKA2 G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; flocculation; establishment of cell polarity (sensu Saccharomyces); regulation of transcription from Pol I promoter; regulation of transcription from Pol III promoter; protein amino acid phosphorylation; cell ion homeostasis; response to DNA damage stimulus; protein kinase CK2 complex; 03 04 14 MCM1 DNA replication initiation; regulation of transcription from Pol II promoter; nuclear chromatin; nucleus; 01 11 03 04 14 ### CLUSTER 59 ### 00 Not clear SHR3 amino acid transport; ER to Golgi transport; integral to endoplasmic reticulum membrane; 06 10 URK1 pyrimidine salvage; 01 PMA1 regulation of pH; proton transport; endoplasmic reticulum; plasma membrane; 13 YOR161C integral to plasma membrane; AGA1 agglutination during conjugation with cellular fusion; cell wall (sensu Fungi); 14 ### CLUSTER 60 ### 06 Protein fate PCP1 mitochondrion organization and biogenesis; mitochondrial intermembrane space protein import; mitochondrion; 06 AFG3 protein complex assembly; proteolysis and peptidolysis; mitochondrial intermembrane space protein import; mitochondrial inner membrane; m-AAA complex; 06 ### CLUSTER 61 ### 03 Cell cycle & DNA processing YDL114W 03 RCK1 protein amino acid phosphorylation; regulation of meiosis; 03 YEL023C 14 GYP7 vesicle-mediated transport; ### CLUSTER 62 ### 00 Not clear YLR352W SNG1 response to drug; membrane; 11 HXT12 01 ### CLUSTER 63 ### 01 Metabolism YLR156W HXT15 hexose transport; plasma membrane; 01 ### CLUSTER 64 ### 13 Regulation/Integration with environment YPD1 response to osmotic stress; osmosensory signaling pathway via two-component system; cytoplasm; 13 SSK22 activation of MAPKK (osmolarity sensing); protein amino acid phosphorylation; osmosensory signaling pathway; 11 13 ### CLUSTER 65 ### 11 Cell rescue/Defense PTP3 inactivation of MAPK (osmolarity sensing); signal transduction during conjugation with cellular fusion; protein amino acid dephosphorylation; cytoplasm; 14 03 SLN1 protein amino acid phosphorylation; osmosensory signaling pathway via two-component system; response to hydrogen peroxide; plasma membrane; 10 13 01 11 PBS2 activation of MAPK (osmolarity sensing); protein amino acid phosphorylation; actin filament organization; osmosensory signaling pathway; cytoplasm; 01 13 11 SHO1 pseudohyphal growth; osmosensory signaling pathway via Sho1 osmosensor; plasma membrane; shmoo tip; 13 11 PTC1 mitochondrion inheritance; tRNA splicing; protein amino acid dephosphorylation; response to osmotic stress; nucleus; cytoplasm; 01 13 11 14 ### CLUSTER 66 ### 06 Protein fate HSE1 protein-vacuolar targeting; endosome; 06 CUE3 ### CLUSTER 67 ### 06 Protein fate DDI1 ubiquitin-dependent protein catabolism; vesicle-mediated transport; plasma membrane; 11 CPS1 proteolysis and peptidolysis; nitrogen metabolism; vacuole (sensu Fungi); 01 06 UFD2 ubiquitin-dependent protein catabolism; response to stress; 06 ### CLUSTER 68 ### 11 Cell rescue/Defense UBC5 protein polyubiquitination; protein monoubiquitination; endocytosis; response to stress; response to unfolded protein; sporulation (sensu Saccharomyces); proteasome complex (sensu Eukarya); 14 08 11 06 UBC4 protein polyubiquitination; protein monoubiquitination; response to stress; sporulation (sensu Saccharomyces); proteasome complex (sensu Eukarya); 14 06 11 08 ### CLUSTER 69 ### 00 Not clear YGR226C YEL073C YIL055C ### CLUSTER 70 ### 03 Cell cycle & DNA processing OKP1 chromosome segregation; condensed nuclear chromosome kinetochore; 03 SPO77 sporulation (sensu Saccharomyces); SFP1 regulation of cell size; nucleus; 03 14 ### CLUSTER 71 ### 01 Metabolism GPI1 GPI anchor biosynthesis; membrane; 14 01 10 COQ3 ubiquinone metabolism; ubiquinone biosynthesis; mitochondrion; mitochondrial inner membrane; extrinsic to membrane; 01 ZRG17 zinc ion transport; YOX1 negative regulation of transcription from Pol II promoter\, mitotic; regulation of mitotic cell cycle; nucleus; 04 ### CLUSTER 72 ### 03 Cell cycle & DNA processing REB1 regulation of transcription from Pol II promoter; transcription termination from Pol I promoter; nucleus; 04 TOF2 DNA topological change; cell; SCT1 phospholipid biosynthesis; CLU1 translational initiation; mitochondrion organization and biogenesis; cytoplasm; eukaryotic translation initiation factor 3 complex; 05 YMR233W TOP2 regulation of mitotic recombination; DNA topological change; DNA strand elongation; chromatin assembly/disassembly; meiotic recombination; synaptonemal complex; nucleus; 03 TOF1 DNA topological change; cell; 03 YFR016C PHB2 replicative cell aging; proteolysis and peptidolysis; mitochondrion; mitochondrial inner membrane; 03 YHL010C ### CLUSTER 73 ### 01 Metabolism YJL055W YIR036C 01 ### CLUSTER 74 ### 01 Metabolism SKT5 cytokinesis; cell wall chitin biosynthesis; response to osmotic stress; contractile ring (sensu Saccharomyces); 14 01 YPC1 ceramide metabolism; endoplasmic reticulum; 01 YNR073C 01 NPT1 chromatin silencing at ribosomal DNA (rDNA); chromatin silencing at telomere; nicotinate nucleotide biosynthesis\, salvage pathway; nucleus; 01 NHA1 monovalent inorganic cation homeostasis; plasma membrane; 13 YMR118C 02 NFU1 iron ion homeostasis; mitochondrial matrix; 01 13 MAK32 virus-host interaction; ### CLUSTER 75 ### 00 Not clear YJR011C YDR366C ### CLUSTER 76 ### 00 Not clear YHR003C 01 DOM34 protein biosynthesis; 03 05 ### CLUSTER 77 ### 00 Not clear TRK1 potassium ion homeostasis; plasma membrane; 13 08 COQ6 ubiquinone metabolism; mitochondrion; mitochondrial inner membrane; 01 ### CLUSTER 78 ### 03 Cell cycle & DNA processing YFR038W 03 YDR334W 04 RDH54 double-strand break repair via break-induced replication; meiotic recombination; heteroduplex formation; nucleus; 03 FUN30 chromosome organization and biogenesis (sensu Eukarya); 03 YNL019C CHD1 chromatin modeling; RNA elongation from Pol II promoter; transcription elongation factor complex; 04 ISW1 chromatin modeling; nucleus; 04 ### CLUSTER 79 ### 03 Cell cycle & DNA processing YLR247C RFX1 DNA damage response\, signal transduction resulting in cell cycle arrest; negative regulation of transcription from Pol II promoter; nucleus; cytoplasm; 04 YNG2 chromatin modification; histone acetyltransferase complex; nucleus; YJR119C 04 RSC2 chromatin modeling; nucleosome remodeling complex; 03 BDF1 sporulation (sensu Saccharomyces); nucleus; 14 04 RSC4 chromatin modeling; nucleosome remodeling complex; 03 RSC1 chromatin modeling; nucleosome remodeling complex; 03 CDA2 spore wall assembly (sensu Saccharomyces); chitosan layer of spore wall; 01 14 ### CLUSTER 80 ### 00 Not clear VPS20 late endosome to vacuole transport; cytoplasm; endosome; ARP4 establishment and/or maintenance of chromatin architecture; regulation of transcription\, DNA-dependent; regulation of transcription from Pol II promoter; histone acetylation; histone acetyltransferase complex; nuclear chromatin; nucleus; KRE27 VID21 TRA1 regulation of transcription from Pol II promoter; histone acetylation; histone acetyltransferase complex; 04 EPL1 regulation of transcription from Pol II promoter; histone acetylation; histone acetyltransferase complex; ### CLUSTER 81 ### 03 Cell cycle & DNA processing SPT6 establishment and/or maintenance of chromatin architecture; nucleosome assembly; regulation of transcription\, DNA-dependent; RNA elongation from Pol II promoter; nucleus; transcription elongation factor complex; 03 04 SPT4 establishment and/or maintenance of chromatin architecture; regulation of transcription\, DNA-dependent; RNA elongation from Pol II promoter; chromosome segregation; nucleus; transcription elongation factor complex; 03 04 ### CLUSTER 82 ### 04 Transcription/RNA processing/RNA transport HIR1 regulation of transcription from Pol II promoter; chromosome\, pericentric region; nucleus; 04 03 SNF11 chromatin modeling; nucleosome remodeling complex; SWI/SNF complex; 14 04 01 SNF6 chromatin modeling; nucleosome remodeling complex; SWI/SNF complex; 01 04 14 SNF5 chromatin modeling; nucleosome remodeling complex; SWI/SNF complex; 04 01 14 STH1 chromatin modeling; meiosis; nucleus; 04 03 RAD5 DNA repair; nuclear chromatin; 03 HIR2 regulation of transcription from Pol II promoter; nucleus; 04 03 SWI3 chromatin modeling; nucleosome remodeling complex; SWI/SNF complex; 14 04 01 RSC8 chromatin modeling; nucleus; nucleosome remodeling complex; 03 04 SUC2 sucrose catabolism; extracellular; cytoplasm; 01 ### CLUSTER 83 ### 04 Transcription/RNA processing/RNA transport RPH1 negative regulation of transcription from Pol II promoter; DNA repair; nucleus; 04 GIS1 intracellular signaling cascade; 03 MOT3 transcription; nucleus; 04 ### CLUSTER 84 ### 01 Metabolism GNT1 N-linked glycosylation; Golgi medial cisterna; BIO3 biotin biosynthesis; cytoplasm; 01 ### CLUSTER 85 ### 01 Metabolism SCS2 myo-inositol metabolism; protein-ER targeting; endoplasmic reticulum; integral to membrane; 01 04 INO2 phospholipid biosynthesis; positive regulation of transcription from Pol II promoter; nucleus; 01 04 CHO2 phosphatidylcholine biosynthesis; endoplasmic reticulum; 01 CHO1 phosphatidylserine biosynthesis; endoplasmic reticulum; 01 OPI1 negative regulation of transcription from Pol II promoter; phospholipid biosynthesis; nucleus; 01 04 ### CLUSTER 86 ### 05 Protein synthesis TYS1 amino acid activation; tyrosyl-tRNA aminoacylation; nucleus; cytoplasm; 05 BCK2 regulation of cell cycle; G1/S transition of mitotic cell cycle; ### CLUSTER 87 ### 01 Metabolism YLR422W RTG3 transcription initiation from Pol II promoter; nucleus; cytoplasm; 01 04 YNR064C RTG1 transcription initiation from Pol II promoter; protein localization; nucleus; cytoplasm; 01 04 RTG2 intracellular signaling cascade; cytoplasm; 01 ### CLUSTER 88 ### 01 Metabolism SIN3 chromatin silencing at ribosomal DNA (rDNA); chromatin silencing at HML and HMR (sensu Saccharomyces); chromatin silencing at telomere; regulation of transcription from Pol II promoter; histone deacetylase complex; 01 14 04 RPD3 chromatin silencing at ribosomal DNA (rDNA); loss of chromatin silencing during replicative cell aging; mitotic recombination; establishment and/or maintenance of chromatin architecture; chromatin silencing; chromatin silencing at HML and HMR (sensu Saccharomyces); chromatin silencing at telomere; regulation of transcription\, DNA-dependent; protein amino acid deacetylation; histone deacetylase complex; 01 04 14 03 ECM16 ribosome biogenesis; processing of 20S pre-rRNA; nucleolus; small nucleolar ribonucleoprotein complex; ### CLUSTER 89 ### 04 Transcription/RNA processing/RNA transport STB1 G1/S transition of mitotic cell cycle; nucleus; 04 PHO23 chromatin modification; histone deacetylase complex; nucleus; 04 ABF2 mitochondrion inheritance; mitochondrial genome maintenance; mitochondrial chromosome; 03 TRK2 potassium ion homeostasis; plasma membrane; 08 RXT2 conjugation with cellular fusion; invasive growth; RCO1 SAP30 chromatin silencing at ribosomal DNA (rDNA); chromatin silencing at HML and HMR (sensu Saccharomyces); chromatin silencing at telomere; histone deacetylase complex; 14 04 STB2 histone deacetylation; nucleus; Sin3 complex; 04 SDS3 transcriptional gene silencing; histone deacetylation; histone deacetylase complex; 14 04 STB4 nucleus; 04 STB3 04 STB6 04 STB5 response to xenobiotic stimulus; nucleus; 04 IOC3 chromatin modeling; nucleus; ### CLUSTER 90 ### 00 Not clear PFK1 glycolysis; cytoplasm; 6-phosphofructokinase complex; 01 02 IME4 meiosis; mRNA modification; 04 14 ### CLUSTER 91 ### 03 Cell cycle & DNA processing UME6 negative regulation of transcription\, mitotic; entry into meiosis; nucleus; 01 04 03 IME2 protein amino acid phosphorylation; regulation of meiosis; nucleus; 03 14 RME1 negative regulation of transcription from Pol II promoter; meiosis; nucleus; 03 04 IDS2 meiosis; 14 10 03 RIM15 protein amino acid phosphorylation; response to stress; regulation of meiosis; 06 04 PMD1 sporulation; 14 YVH1 meiosis; sporulation (sensu Saccharomyces); 14 03 13 ### CLUSTER 92 ### 01 Metabolism ARG80 arginine metabolism; positive regulation of transcription from Pol II promoter; nucleus; 01 04 HMRA2 14 HMLALPHA2 regulation of transcription from Pol II promoter; regulation of transcription\, mating-type specific; donor preference; nucleus; 14 ARG82 arginine metabolism; phosphorylation; nucleus; 01 14 04 ARG81 arginine metabolism; negative regulation of calcium ion dependent exocytosis; nucleus; 01 04 LYS7 intracellular copper ion transport; cytosol; 11 06 13 ### CLUSTER 93 ### 03 Cell cycle & DNA processing MIF2 mitotic spindle assembly (sensu Saccharomyces); condensed nuclear chromosome kinetochore; nucleus; 03 CBF2 chromosome segregation; condensed nuclear chromosome kinetochore; 03 ### CLUSTER 94 ### 00 Not clear YLR050C VAC17 vacuole inheritance; vacuolar membrane; ### CLUSTER 95 ### 01 Metabolism PHO3 thiamin transport; periplasmic space (sensu Fungi); 01 PHO11 phosphate metabolism; extracellular; 01 ### CLUSTER 96 ### 00 Not clear YDR267C FIR1 mRNA polyadenylation; 04 OSH3 steroid biosynthesis; cytoplasm; 01 ### CLUSTER 97 ### 03 Cell cycle & DNA processing SPC34 mitotic spindle assembly (sensu Saccharomyces); microtubule nucleation; condensed nuclear chromosome kinetochore; spindle pole body; spindle; 03 ASK1 mitotic spindle assembly (sensu Saccharomyces); condensed nuclear chromosome kinetochore; condensed nuclear chromosome\, pericentric region; spindle; 03 ### CLUSTER 98 ### 03 Cell cycle & DNA processing SLI15 protein amino acid phosphorylation; chromosome segregation; kinetochore microtubule; spindle microtubule; 03 DUO1 mitotic spindle assembly (sensu Saccharomyces); condensed nuclear chromosome kinetochore; spindle; 03 YGL036W DEP1 regulation of transcription from Pol II promoter; phospholipid metabolism; 01 DAD1 mitotic spindle assembly (sensu Saccharomyces); condensed nuclear chromosome kinetochore; spindle; 03 ### CLUSTER 99 ### 03 Cell cycle & DNA processing TUB2 nuclear migration (sensu Saccharomyces); mitotic chromosome segregation; nuclear migration during conjugation with cellular fusion; homologous chromosome segregation; spindle pole body; polar microtubule; kinetochore microtubule; nuclear microtubule; cytoplasmic microtubule; 03 PAC2 post-chaperonin tubulin folding pathway; alpha-tubulin folding; 03 BIM1 nuclear migration (sensu Saccharomyces); microtubule depolymerization; microtubule nucleation; microtubule stabilization; mitotic spindle checkpoint; spindle pole body; cytoplasmic microtubule; 03 ### CLUSTER 100 ### 06 Protein fate VAC8 vacuole inheritance; protein-vacuolar targeting; microautophagy; homotypic vacuole fusion (non-autophagic); vacuole (sensu Fungi); 06 APG1 06 08 14 ### CLUSTER 101 ### 08 Cellular transport PAC11 microtubule-based process; cell; 03 14 08 DID4 protein-Golgi retention; late endosome to vacuole transport; cytoplasm; endosome; 06 08 TID3 microtubule nucleation; chromosome segregation; condensed nuclear chromosome kinetochore; condensed nuclear chromosome\, pericentric region; 03 YIL083C coenzyme A biosynthesis; intracellular; YGR052W mitochondrion; ### CLUSTER 102 ### 00 Not clear YHR033W cytoplasm; 01 YCR079W SRV2 cytoskeleton organization and biogenesis; RAS protein signal transduction; actin cortical patch (sensu Saccharomyces); 10 14 COT1 cobalt ion transport; zinc ion transport; zinc ion homeostasis; vacuole (sensu Fungi); 08 13 ### CLUSTER 103 ### 08 Cellular transport CAX4 N-linked glycosylation; lipid biosynthesis; integral to endoplasmic reticulum membrane; 06 GCN1 regulation of translational elongation; cytosol; cytosolic ribosome (sensu Eukarya); 05 TPM1 mitochondrion inheritance; vacuole inheritance; establishment of cell polarity (sensu Saccharomyces); exocytosis; actin filament organization; apical bud growth; isotropic bud growth; actin polymerization and/or depolymerization; mRNA localization\, intracellular; vesicle-mediated transport; actin cable assembly; actin cable (sensu Saccharomyces); contractile ring (sensu Saccharomyces); 14 08 YPT11 mitochondrion inheritance; incipient bud site; bud tip; bud neck; 08 SMY1 exocytosis; bud tip; bud neck; 14 08 UBP15 protein deubiquitination; cytoplasm; 06 MYO1 cytokinesis; response to osmotic stress; axial budding; contractile ring (sensu Saccharomyces); 03 14 08 CTR9 transcription from Pol II promoter; RNA elongation from Pol II promoter; chromosome segregation; nucleus; transcription elongation factor complex; Cdc73/Paf1 complex; 03 SAM1 methionine metabolism; cytoplasm; 01 ### CLUSTER 104 ### 08 Cellular transport JNM1 mitotic anaphase B; dynactin complex; 03 08 NUP1 RNA-nucleus export; mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; protein-nucleus import; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear membrane organization and biogenesis; nuclear pore organization and biogenesis; nuclear pore; 08 MSO1 nonselective vesicle docking; sporulation (sensu Saccharomyces); microsome; 08 ### CLUSTER 105 ### 08 Cellular transport POL1 DNA repair synthesis; DNA replication\, priming; DNA replication initiation; lagging strand elongation; alpha DNA polymerase\:primase complex; 03 MYO2 mitochondrion inheritance; vacuole inheritance; establishment of cell polarity (sensu Saccharomyces); endocytosis; apical bud growth; isotropic bud growth; vesicle-mediated transport; actin cable (sensu Saccharomyces); actin cap (sensu Saccharomyces); 08 14 RUD3 ER to Golgi transport; Golgi apparatus; 08 APG17 06 14 YNL136W ULP1 G2/M transition of mitotic cell cycle; protein desumoylation; nuclear membrane; nuclear pore; 06 YPL260W GYP5 vesicle-mediated transport; soluble fraction; cytosol; VTA1 late endosome to vacuole transport; SLK19 mitotic spindle assembly (sensu Saccharomyces); meiosis; condensed nuclear chromosome kinetochore; spindle; 03 DNF3 intracellular protein transport; trans-Golgi network transport vesicle; IWS1 RNA elongation from Pol II promoter; transcription elongation factor complex; BBP1 microtubule nucleation; spindle pole body; 14 03 ARF3 intracellular protein transport; 08 06 TFP3 vacuolar acidification; hydrogen-transporting ATPase V0 domain; 13 08 06 NIP100 mitotic anaphase B; dynactin complex; 08 14 03 KIP2 nuclear migration (sensu Saccharomyces); mitotic anaphase B; microtubule stabilization; kinesin complex; cytoplasmic microtubule; 03 08 VIK1 microtubule-based process; spindle pole body; kinesin complex; STU1 microtubule nucleation; spindle pole body; CIN4 microtubule-based process; 03 SRT1 protein amino acid glycosylation; lipid particle; 06 DYN1 mitotic spindle elongation; nuclear migration (sensu Saccharomyces); mitotic chromosome segregation; mitotic spindle orientation; spindle pole body; cytoplasmic microtubule; 08 03 MLP1 protein-nucleus import; nuclear membrane; nucleoplasm; 03 IMH1 vesicle-mediated transport; cytosol; 06 08 BRO1 ubiquitin-dependent protein catabolism; vacuolar transport; signal transduction; cytoplasm; endosome; 13 11 ARP5 protein-vacuolar targeting; nucleus; ### CLUSTER 106 ### 00 Not clear KEL2 conjugation with cellular fusion; bud tip; bud neck; shmoo tip; 14 13 BRE1 chromatin silencing at telomere; protein monoubiquitination; histone methylation; histone ubiquitination; nucleus; ### CLUSTER 107 ### 03 Cell cycle & DNA processing ADY3 protein complex assembly; spore wall assembly (sensu Saccharomyces); sporulation; prospore membrane; spindle; YLL032C YLR431C STU2 mitotic spindle assembly (sensu Saccharomyces); microtubule nucleation; spindle pole body; BIK1 mitotic anaphase B; mitotic spindle assembly; spindle pole body; spindle microtubule; 14 03 SHE9 mitochondrion organization and biogenesis; inner mitochondrial membrane organization and biogenesis; mitochondrial inner membrane; CIN8 mitotic chromosome segregation; mitotic spindle assembly (sensu Saccharomyces); mitotic anaphase B; kinesin complex; spindle microtubule; 03 08 YMR031C SNX4 transport; autophagy; membrane; 06 CIK1 mitotic chromosome segregation; mitotic spindle assembly (sensu Saccharomyces); mitotic spindle orientation; meiosis; spindle pole body; spindle; kinesin complex; cytoplasmic microtubule; 08 03 SMC5 DNA repair; cell proliferation; nucleus; 03 TOP1 regulation of mitotic recombination; DNA topological change; DNA strand elongation; chromatin assembly/disassembly; regulation of transcription from Pol II promoter; RNA elongation from Pol II promoter; mitotic chromosome condensation; nuclear migration; nucleus; 03 04 SPO21 meiosis; spore wall assembly (sensu Saccharomyces); spindle pole body; 03 MPC54 spore wall assembly (sensu Saccharomyces); spindle pole body; 03 YLR254C KIP1 mitotic anaphase B; microtubule nucleation; spindle pole body; kinesin complex; spindle microtubule; 03 08 COY1 Golgi vesicle transport; Golgi membrane; 03 YML119W YGR130C cytoplasm; KEL1 cytogamy; cellular morphogenesis; regulation of cell shape; plasma membrane fusion; cytoplasm; bud tip; bud neck; shmoo tip; 14 13 PLO2 YDR532C TPM2 mitochondrion inheritance; vacuole inheritance; establishment of cell polarity (sensu Saccharomyces); exocytosis; actin filament organization; apical bud growth; isotropic bud growth; actin polymerization and/or depolymerization; mRNA localization\, intracellular; vesicle-mediated transport; actin cable assembly; actin cable (sensu Saccharomyces); contractile ring (sensu Saccharomyces); 14 NUM1 nuclear migration (sensu Saccharomyces); microtubule cytoskeleton organization and biogenesis; bud tip; cell cortex; 03 ### CLUSTER 108 ### 04 Transcription/RNA processing/RNA transport SAS3 chromatin silencing at HML and HMR (sensu Saccharomyces); chromatin silencing at telomere; chromatin modification; nuclear nucleosome; 04 14 SNF2 chromatin modeling; nucleosome remodeling complex; SWI/SNF complex; 01 04 14 TAF3 G1-specific transcription in mitotic cell cycle; transcription initiation from Pol II promoter; transcription factor TFIID complex; 04 TFG2 transcription initiation from Pol II promoter; transcription factor TFIIF complex; 04 TFG1 transcription initiation from Pol II promoter; transcription factor TFIIF complex; 04 MGM1 mitochondrial genome maintenance; mitochondrion organization and biogenesis; mitochondrial fusion; mitochondrial intermembrane space; ### CLUSTER 109 ### 04 Transcription/RNA processing/RNA transport RTF1 transcription from Pol II promoter; RNA elongation from Pol II promoter; transcription elongation factor complex; Cdc73/Paf1 complex; 04 PAF1 RNA elongation from Pol II promoter; transcription elongation factor complex; 04 CDC73 RNA elongation from Pol II promoter; transcription elongation factor complex; 04 SPT5 establishment and/or maintenance of chromatin architecture; regulation of transcription\, DNA-dependent; RNA elongation from Pol II promoter; nucleus; transcription elongation factor complex; 04 03 HOT1 regulation of transcription from Pol II promoter; hyperosmotic response; nuclear chromosome; ### CLUSTER 110 ### 04 Transcription/RNA processing/RNA transport RIC1 intracellular protein transport; nucleus; Golgi apparatus; 04 RPG1 translational initiation; incipient bud site; cytoplasm; ribosome; eukaryotic translation initiation factor 3 complex; 05 03 HCR1 protein biosynthesis; eukaryotic translation initiation factor 3 complex; 04 TFC7 transcription initiation from Pol III promoter; transcription factor TFIIIC complex; 01 04 GAL4 galactose metabolism; regulation of transcription\, DNA-dependent; nucleus; 01 04 YAH1 heme a biosynthesis; mitochondrial matrix; SNF8 protein-vacuolar targeting; negative regulation of transcription by glucose; endosome; 01 YCR051W TIF34 translational initiation; eukaryotic translation initiation factor 3 complex; 05 NIP1 translational initiation; cytoplasm; eukaryotic translation initiation factor 3 complex; 05 ### CLUSTER 111 ### 04 Transcription/RNA processing/RNA transport TFC4 transcription initiation from Pol III promoter; transcription factor TFIIIC complex; 04 TFC1 transcription initiation from Pol III promoter; transcription factor TFIIIC complex; 04 ### CLUSTER 112 ### 04 Transcription/RNA processing/RNA transport TOA1 transcription initiation from Pol II promoter; transcription factor TFIIA complex; 04 PRT1 translational initiation; cytoplasm; eukaryotic translation initiation factor 3 complex; 05 03 14 TOA2 transcription initiation from Pol II promoter; transcription factor TFIIA complex; 04 IST2 response to osmotic stress; GLT1 glutamate biosynthesis; cell; 01 YOR262W VPS36 protein-vacuolar targeting; negative regulation of transcription by glucose; protein-Golgi retention; endosome; 06 ### CLUSTER 113 ### 04 Transcription/RNA processing/RNA transport RLM1 cell wall organization and biogenesis; signal transduction; positive regulation of transcription from Pol II promoter; nucleus; 04 14 YER184C 04 MAL13 carbohydrate metabolism; regulation of transcription\, DNA-dependent; nucleus; 01 04 MSS1 protein biosynthesis; mitochondrial inner membrane; 04 05 HAP4 regulation of carbohydrate metabolism; transcription; CCAAT-binding factor complex; 04 GAL11 transcription from Pol II promoter; mediator complex; 14 04 01 APL1 vesicle-mediated transport; AP-2 adaptor complex; 08 06 MHR1 mitochondrial genome maintenance; nucleus; mitochondrion; 03 GAL80 galactose metabolism; regulation of transcription\, DNA-dependent; nucleus; cytoplasm; 01 04 HAP5 regulation of carbohydrate metabolism; transcription; CCAAT-binding factor complex; 04 PPR1 regulation of transcription\, DNA-dependent; uracil biosynthesis; nucleus; 01 04 HIS3 histidine biosynthesis; cell; 01 SRB2 transcription from Pol II promoter; mediator complex; 04 RPT4 ubiquitin-dependent protein catabolism; nucleus; proteasome regulatory particle (sensu Eukarya); proteasome regulatory particle\, base subcomplex (sensu Eukarya); 04 06 GAL3 galactose metabolism; regulation of transcription\, DNA-dependent; cytoplasm; 04 01 GAL1 galactose metabolism; 01 04 HAP1 aerobic respiration; positive regulation of transcription from Pol II promoter; nucleus; 04 ### CLUSTER 114 ### 01 Metabolism GAL7 galactose metabolism; cytoplasm; 01 GAL10 galactose metabolism; 01 ### CLUSTER 115 ### 04 Transcription/RNA processing/RNA transport SRB8 negative regulation of transcription from Pol II promoter; transcription factor complex; 04 01 RGR1 transcription from Pol II promoter; mediator complex; 01 14 04 02 PGD1 transcription from Pol II promoter; mediator complex; 03 04 MED6 transcription from Pol II promoter; mediator complex; 04 MED2 transcription from Pol II promoter; mediator complex; 04 ROX3 transcription from Pol II promoter; mediator complex; nucleus; 04 11 MKS1 regulation of nitrogen utilization; intracellular; 01 04 SRB6 transcription from Pol II promoter; mediator complex; 01 14 04 SRB5 transcription from Pol II promoter; mediator complex; 04 SRB4 transcription from Pol II promoter; mediator complex; 04 SRB7 transcription from Pol II promoter; mediator complex; 04 TFA2 transcription initiation from Pol II promoter; transcription factor TFIIE complex; 04 TFA1 transcription initiation from Pol II promoter; transcription factor TFIIE complex; 04 ### CLUSTER 116 ### 04 Transcription/RNA processing/RNA transport YAP7 positive regulation of transcription from Pol II promoter; nucleus; 04 SIN4 transcription from Pol II promoter; mediator complex; 14 01 04 ### CLUSTER 117 ### 04 Transcription/RNA processing/RNA transport TAF6 G1-specific transcription in mitotic cell cycle; establishment and/or maintenance of chromatin architecture; transcription initiation from Pol II promoter; protein amino acid acetylation; chromatin modification; histone acetylation; SAGA complex; transcription factor TFIID complex; 04 TAF12 G1-specific transcription in mitotic cell cycle; establishment and/or maintenance of chromatin architecture; transcription initiation from Pol II promoter; protein amino acid acetylation; chromatin modification; histone acetylation; SAGA complex; transcription factor TFIID complex; 04 NGG1 chromatin modification; histone acetylation; SAGA complex; 01 04 ADA2 chromatin modification; histone acetylation; SAGA complex; 04 ADR1 regulation of carbohydrate metabolism; transcription; peroxisome organization and biogenesis; nucleus; 04 01 SPT7 conjugation with cellular fusion; protein complex assembly; chromatin modification; histone acetylation; SAGA complex; 04 SPT3 conjugation with cellular fusion; pseudohyphal growth; invasive growth; chromatin modification; histone acetylation; sporulation (sensu Fungi); SAGA complex; 14 04 TAF2 G1-specific transcription in mitotic cell cycle; transcription initiation from Pol II promoter; transcription factor TFIID complex; 04 ### CLUSTER 118 ### 04 Transcription/RNA processing/RNA transport SPT20 chromatin modification; histone acetylation; SAGA complex; 04 GCN5 chromatin modification; histone acetylation; SAGA complex; 04 03 06 SPT8 chromatin modification; histone acetylation; SAGA complex; nucleus; 04 ### CLUSTER 119 ### 04 Transcription/RNA processing/RNA transport POP1 rRNA processing; tRNA processing; ribonuclease MRP complex; nucleolar ribonuclease P complex; 04 CSI1 protein deneddylation; adaptation to pheromone during conjugation with cellular fusion; signalosome complex; CBT1 mRNA processing; cytochrome biogenesis; 04 ### CLUSTER 120 ### 03 Cell cycle & DNA processing SAP190 G1/S transition of mitotic cell cycle; cytoplasm; 03 14 YCK3 protein amino acid phosphorylation; nucleus; plasma membrane; 03 PFS1 spore wall assembly (sensu Fungi); 14 YCK2 cellular morphogenesis; cytokinesis; protein amino acid phosphorylation; endocytosis; plasma membrane; bud neck; 14 11 03 08 TGL1 lipid metabolism; lipid particle; 01 CAF40 regulation of transcription from Pol II promoter; CCR4-NOT complex; RIO2 processing of 20S pre-rRNA; nucleus; cytosol; ### CLUSTER 121 ### 04 Transcription/RNA processing/RNA transport TOM1 protein polyubiquitination; protein monoubiquitination; nucleocytoplasmic transport; nuclear organization and biogenesis; mitosis; 03 SSN2 negative regulation of transcription from Pol II promoter; transcription factor complex; 04 01 DBF2 nuclear division; protein amino acid phosphorylation; spindle pole body; bud neck; 03 04 YAK1 protein amino acid phosphorylation; cell growth and/or maintenance; nucleus; cytoplasm; 03 DHH1 mRNA catabolism\, nonsense-mediated; deadenylation-dependent decapping; cytoplasmic mRNA processing body; cytoplasm; 04 CDC39 regulation of cell cycle; negative regulation of transcription from Pol II promoter; mRNA catabolism\, deadenylation-dependent; poly(A) tail shortening; response to pheromone during conjugation with cellular fusion; regulation of transcription from Pol II promoter; nucleus; cytoplasm; CCR4-NOT core complex; 14 04 CCR4 mRNA catabolism\, deadenylation-dependent; poly(A) tail shortening; regulation of transcription from Pol II promoter; cytoplasm; CCR4-NOT core complex; 01 04 CDC36 regulation of cell cycle; negative regulation of transcription from Pol II promoter; mRNA catabolism\, deadenylation-dependent; poly(A) tail shortening; response to pheromone during conjugation with cellular fusion; regulation of transcription from Pol II promoter; nucleus; cytoplasm; CCR4-NOT core complex; 03 04 CAF130 regulation of transcription from Pol II promoter; CCR4-NOT complex; NOT3 poly(A) tail shortening; regulation of transcription from Pol II promoter; cytoplasm; CCR4-NOT core complex; 04 MOT2 poly(A) tail shortening; conjugation with cellular fusion; regulation of transcription from Pol II promoter; cytoplasm; CCR4-NOT core complex; 14 04 ### CLUSTER 122 ### 00 Not clear YMR247C YMR115W RAT1 35S primary transcript processing; RNA processing; nucleus; 04 08 ### CLUSTER 123 ### 00 Not clear PTC4 PTC3 regulation of CDK activity; inactivation of MAPK (osmolarity sensing); protein amino acid dephosphorylation; ### CLUSTER 124 ### 00 Not clear YLR446W SWI1 chromatin modeling; nucleosome remodeling complex; SWI/SNF complex; 01 14 04 NUD1 microtubule nucleation; spindle pole body; 03 ### CLUSTER 125 ### 04 Transcription/RNA processing/RNA transport YAP5 positive regulation of transcription from Pol II promoter; nucleus; 04 ADP1 transport; cytoplasm; endoplasmic reticulum; integral to membrane; EAP1 negative regulation of translation; mRNA cap complex; 05 CTL1 RNA processing; nucleus; cytoplasm; 04 YCK1 cellular morphogenesis; cytokinesis; protein amino acid phosphorylation; endocytosis; endoplasmic reticulum; plasma membrane; 11 14 08 03 ### CLUSTER 126 ### 00 Not clear RPN2 ubiquitin-dependent protein catabolism; proteasome regulatory particle (sensu Eukarya); 06 04 ADE16 'de novo' IMP biosynthesis; sporulation (sensu Saccharomyces); aerobic respiration; cytosol; 01 ### CLUSTER 127 ### 00 Not clear DSK2 spindle pole body duplication (sensu Saccharomyces); nucleus; 03 NAS2 ubiquitin-dependent protein catabolism; cytoplasm; 14 ENT3 actin cortical patch assembly; Golgi to endosome transport; endocytosis; actin filament organization; actin cortical patch (sensu Saccharomyces); clathrin vesicle coat; ### CLUSTER 128 ### 14 Cell fate YNL026W TWF1 polar budding; actin polymerization and/or depolymerization; actin cortical patch (sensu Saccharomyces); 14 ### CLUSTER 129 ### 11 Cell rescue/Defense CWP2 regulation of pH; cell wall organization and biogenesis; cell wall (sensu Fungi); TTR1 response to oxidative stress; regulation of redox homeostasis; mitochondrion; cytosol; 01 11 TRX2 vacuole inheritance; DNA dependent DNA replication; response to oxidative stress; regulation of redox homeostasis; vacuole fusion (non-autophagic); vacuole (sensu Fungi); cytosol; 03 06 11 ### CLUSTER 130 ### 00 Not clear YML131W 01 YIM1 mitochondrial processing; cytoplasm; mitochondrial inner membrane; lipid particle; 06 YNL134C ### CLUSTER 131 ### 03 Cell cycle & DNA processing TPD3 protein biosynthesis; protein amino acid dephosphorylation; actin filament organization; mitotic spindle checkpoint; bud growth; protein phosphatase type 2A complex; nucleus; cytoplasm; spindle pole body; bud tip; bud neck; shmoo tip; 14 04 03 PPH21 G1/S transition of mitotic cell cycle; protein biosynthesis; protein amino acid dephosphorylation; actin filament organization; mitotic spindle checkpoint; bud growth; protein phosphatase type 2A complex; 01 14 03 PPH22 G1/S transition of mitotic cell cycle; protein biosynthesis; protein amino acid dephosphorylation; actin filament organization; mitotic spindle checkpoint; bud growth; protein phosphatase type 2A complex; 01 14 03 ### CLUSTER 132 ### 00 Not clear YNL311C ubiquitin-dependent protein catabolism; ubiquitin ligase complex; THI20 thiamin biosynthesis; 04 AAD15 aldehyde metabolism; 01 02 ### CLUSTER 133 ### 06 Protein fate UBP5 protein deubiquitination; cytoplasm; 06 PRE3 ubiquitin-dependent protein catabolism; response to stress; sporulation (sensu Saccharomyces); proteasome core complex (sensu Eukarya); proteasome core complex\, beta-subunit complex (sensu Eukarya); 06 14 11 PUP3 ubiquitin-dependent protein catabolism; proteasome core complex (sensu Eukarya); proteasome core complex\, beta-subunit complex (sensu Eukarya); 06 PRE4 ubiquitin-dependent protein catabolism; proteasome core complex (sensu Eukarya); proteasome core complex\, beta-subunit complex (sensu Eukarya); 06 UMP1 protein catabolism; proteasome core complex (sensu Eukarya); 06 YMR148W integral to membrane; YMR099C PRE8 ubiquitin-dependent protein catabolism; proteasome core complex (sensu Eukarya); 06 ### CLUSTER 134 ### 06 Protein fate MVP1 protein-vacuolar targeting; cytoplasm; 06 08 RPT1 ubiquitin-dependent protein catabolism; proteasome regulatory particle (sensu Eukarya); 06 03 YLR387C 06 SGT2 RPN13 proteolysis and peptidolysis; proteasome regulatory particle (sensu Eukarya); PRE6 ubiquitin-dependent protein catabolism; proteasome core complex (sensu Eukarya); proteasome core complex\, alpha-subunit complex (sensu Eukarya); 06 YOR131C SGT1 centromere/kinetochore complex maturation; regulation of cell cycle; protein complex assembly; protein ubiquitination; cAMP-mediated signaling; ubiquitin ligase complex; 06 03 10 UBP2 protein deubiquitination; cytoplasm; 06 RPN8 ubiquitin-dependent protein catabolism; proteasome regulatory particle (sensu Eukarya); proteasome regulatory particle\, lid subcomplex (sensu Eukarya); 06 RET3 retrograde (Golgi to ER) transport; COPI vesicle coat; 08 YPT52 protein-vacuolar targeting; endocytosis; late endosome; 08 06 ### CLUSTER 135 ### 06 Protein fate UBC1 protein polyubiquitination; protein monoubiquitination; endocytosis; germination (sensu Saccharomyces); proteasome complex (sensu Eukarya); 14 06 08 BET4 protein amino acid geranylgeranylation; Rab-protein geranylgeranyltransferase complex; 01 06 IST1 YIR024C 03 PRE9 ubiquitin-dependent protein catabolism; proteasome core complex (sensu Eukarya); 06 YOL107W ECM29 cell wall organization and biogenesis; GLC8 glycogen biosynthesis; cytoplasm; 01 YFR011C RTT103 negative regulation of DNA transposition; ### CLUSTER 136 ### 06 Protein fate RPT6 ubiquitin-dependent protein catabolism; nucleus; proteasome regulatory particle (sensu Eukarya); proteasome regulatory particle\, base subcomplex (sensu Eukarya); 03 06 UBC13 protein polyubiquitination; postreplication repair; protein monoubiquitination; nucleus; cytoplasm; 06 RPN3 ubiquitin-dependent protein catabolism; proteasome regulatory particle (sensu Eukarya); 06 UBP6 protein deubiquitination; proteasome regulatory particle (sensu Eukarya); 06 RPN11 ubiquitin-dependent protein catabolism; proteasome regulatory particle\, lid subcomplex (sensu Eukarya); 06 RPN5 ubiquitin-dependent protein catabolism; proteasome regulatory particle (sensu Eukarya); proteasome regulatory particle\, lid subcomplex (sensu Eukarya); 06 RPT2 ubiquitin-dependent protein catabolism; proteasome regulatory particle (sensu Eukarya); 06 RPN6 ubiquitin-dependent protein catabolism; proteasome regulatory particle (sensu Eukarya); 06 RPT3 ubiquitin-dependent protein catabolism; proteasome regulatory particle (sensu Eukarya); proteasome regulatory particle\, base subcomplex (sensu Eukarya); 06 RPN9 ubiquitin-dependent protein catabolism; proteasome regulatory particle (sensu Eukarya); proteasome regulatory particle\, lid subcomplex (sensu Eukarya); 06 RPN12 ubiquitin-dependent protein catabolism; proteasome regulatory particle (sensu Eukarya); 03 06 11 SCL1 ubiquitin-dependent protein catabolism; proteasome core complex\, alpha-subunit complex (sensu Eukarya); 06 PRE1 ubiquitin-dependent protein catabolism; response to stress; sporulation (sensu Saccharomyces); nucleus; proteasome core complex (sensu Eukarya); proteasome core complex\, beta-subunit complex (sensu Eukarya); 06 11 14 ### CLUSTER 137 ### 06 Protein fate RPN10 ubiquitin-dependent protein catabolism; proteasome regulatory particle (sensu Eukarya); 06 PIL1 ### CLUSTER 138 ### 06 Protein fate PUP1 ubiquitin-dependent protein catabolism; proteasome core complex (sensu Eukarya); proteasome core complex\, beta-subunit complex (sensu Eukarya); 06 PRE5 ubiquitin-dependent protein catabolism; proteasome core complex (sensu Eukarya); proteasome core complex\, alpha-subunit complex (sensu Eukarya); 06 ### CLUSTER 139 ### 00 Not clear SCD6 08 NOT5 poly(A) tail shortening; regulation of transcription from Pol II promoter; cytoplasm; CCR4-NOT core complex; 04 ### CLUSTER 140 ### 08 Cellular transport YOP1 membrane organization and biogenesis; membrane; 08 AGC1 transport; mitochondrial inner membrane; 08 01 SNU66 nuclear mRNA splicing\, via spliceosome; small nuclear ribonucleoprotein complex; 04 ### CLUSTER 141 ### 06 Protein fate RPN7 ubiquitin-dependent protein catabolism; proteasome regulatory particle (sensu Eukarya); 06 NTO1 04 YPL247C YNL095C integral to membrane; CTI6 positive regulation of transcription; nucleus; EPS1 protein-ER retention; endoplasmic reticulum membrane; 06 FCP1 transcription; protein amino acid dephosphorylation; nucleus; 04 SSO1 Golgi to plasma membrane transport; nonselective vesicle fusion; integral to plasma membrane; 08 14 SOG2 CBC2 nuclear mRNA splicing\, via spliceosome; commitment complex; snRNA cap binding complex; 03 04 PUF2 mRNA catabolism\, deadenylation-dependent; ZIP2 synaptonemal complex formation; synaptonemal complex; 03 PSR2 response to stress; plasma membrane; 06 ### CLUSTER 142 ### 00 Not clear SKY1 mRNA splice site selection; cell ion homeostasis; positive regulation of protein-nucleus import; response to drug; cytoplasm; RLR1 DNA recombination; RNA elongation from Pol II promoter; mRNA-nucleus export; THO complex; 05 04 VPS24 late endosome to vacuole transport; cytoplasm; endosome; 06 08 ### CLUSTER 143 ### 01 Metabolism PGU1 pseudohyphal growth; pectin catabolism; extracellular; 01 MAM1 meiotic chromosome segregation; condensed nuclear chromosome kinetochore; ### CLUSTER 144 ### 01 Metabolism AAD10 aldehyde metabolism; 02 01 AAD6 aldehyde metabolism; 01 02 AAD3 aldehyde metabolism; 01 02 SNL1 nuclear pore organization and biogenesis; nuclear membrane; endoplasmic reticulum membrane; membrane; DCG1 nitrogen metabolism; 01 MGM101 mitochondrial genome maintenance; DNA repair; mitochondrial chromosome; 03 CBK1 response to pheromone during conjugation with cellular fusion; cellular morphogenesis during conjugation with cellular fusion; regulation of exit from mitosis; establishment and/or maintenance of cell polarity (sensu Saccharomyces); nucleus; cytoplasm; bud; bud neck; NBP35 nucleus; RNH70 DNA replication; RNA processing; nucleus; 01 HRT3 YOL111C cytoplasm; 06 AAD14 aldehyde metabolism; 01 02 ### CLUSTER 145 ### 01 Metabolism YFR012W BNS1 meiosis; 03 YDR541C 01 YDR476C YBR204C lipid particle; 01 ### CLUSTER 146 ### 11 Cell rescue/Defense SNO1 pyridoxine metabolism; thiamin biosynthesis; 11 SNZ2 pyridoxine metabolism; thiamin biosynthesis; 01 11 OYE2 02 SNZ3 pyridoxine metabolism; thiamin biosynthesis; 11 SNO3 pyridoxine metabolism; thiamin biosynthesis; 11 YMR258C YLR460C ### CLUSTER 147 ### 00 Not clear YLR224W ubiquitin-dependent protein catabolism; ubiquitin ligase complex; AHT1 ### CLUSTER 148 ### 01 Metabolism YDL033C YDL036C 01 CRD1 mitochondrial membrane organization and biogenesis; lipid biosynthesis; mitochondrial membrane; 01 MRPS9 protein biosynthesis; mitochondrial small ribosomal subunit; 05 FMT1 translational initiation; methionyl-tRNA aminoacylation; mitochondrion; 04 ### CLUSTER 149 ### 05 Protein synthesis MRPS28 ribosomal small subunit assembly and maintenance; protein biosynthesis; mitochondrial small ribosomal subunit; 05 RSM23 protein biosynthesis; mitochondrial small ribosomal subunit; 05 EHD3 fatty acid beta-oxidation; endocytosis; RSM10 protein biosynthesis; mitochondrial small ribosomal subunit; 05 ### CLUSTER 150 ### 06 Protein fate YBR219C GIM4 tubulin folding; cytoplasm; 06 ### CLUSTER 151 ### 08 Cellular transport USA1 PEX13 protein-peroxisome targeting; peroxisome organization and biogenesis; peroxisomal membrane; 06 08 PEX5 protein-peroxisome targeting; peroxisome organization and biogenesis; peroxisome; cytosol; 06 08 PEX14 protein-peroxisome targeting; peroxisomal membrane; 06 08 PEX2 peroxisome organization and biogenesis; peroxisomal membrane; 08 PEX1 peroxisome organization and biogenesis; 06 PEX17 peroxisome organization and biogenesis; peroxisomal membrane; 08 ### CLUSTER 152 ### 08 Cellular transport PEX7 protein-peroxisome targeting; peroxisome organization and biogenesis; peroxisomal matrix; cytosol; 06 08 PEX21 protein-peroxisome targeting; peroxisome; cytosol; 06 08 ### CLUSTER 153 ### 03 Cell cycle & DNA processing TUB4 mitotic spindle assembly (sensu Saccharomyces); microtubule nucleation; inner plaque of spindle pole body; outer plaque of spindle pole body; 03 CYB5 sterol biosynthesis; microsome; 01 SPC97 microtubule nucleation; inner plaque of spindle pole body; outer plaque of spindle pole body; 03 ### CLUSTER 154 ### 03 Cell cycle & DNA processing SPC110 microtubule nucleation; inner plaque of spindle pole body; central plaque of spindle pole body; 03 PSK2 protein amino acid phosphorylation; hexose metabolism; KAR1 karyogamy during conjugation with cellular fusion; spindle pole body duplication (sensu Saccharomyces); half bridge of spindle pole body; 14 03 ### CLUSTER 155 ### 03 Cell cycle & DNA processing SPC29 microtubule nucleation; spindle pole body duplication (sensu Saccharomyces); central plaque of spindle pole body; 03 MPS2 mitotic anaphase; spindle pole body duplication (sensu Saccharomyces); nuclear membrane; spindle pole body; 03 NUF2 microtubule nucleation; chromosome segregation; condensed nuclear chromosome kinetochore; condensed nuclear chromosome\, pericentric region; 03 SPC42 microtubule nucleation; spindle pole body duplication (sensu Saccharomyces); intermediate layer of spindle pole body; central plaque of spindle pole body; 03 LRS4 chromatin silencing at ribosomal DNA (rDNA); meiosis I\, chromosome segregation; nuclear chromosome; nucleus; nucleolus; 04 ECM11 cell wall organization and biogenesis; nucleus; ### CLUSTER 156 ### 08 Cellular transport DRS2 intracellular protein transport; post-Golgi transport; Golgi membrane; trans-Golgi network transport vesicle; 08 ARF2 ER to Golgi transport; intra-Golgi transport; Golgi vesicle; cytosol; 06 08 ### CLUSTER 157 ### 01 Metabolism FAP1 SPP41 negative regulation of transcription from Pol II promoter; 04 HMO1 plasmid maintenance; nuclear chromatin; nucleus; cytoplasm; TOR2 regulation of cell cycle; G1 phase of mitotic cell cycle; cytoskeleton organization and biogenesis; ribosome biogenesis; signal transduction; Rho protein signal transduction; cell cycle dependent actin filament reorganization; vacuolar membrane; plasma membrane; 01 03 14 10 HOM3 methionine metabolism; threonine metabolism; homoserine biosynthesis; 01 YMR087W YIL089W SSL1 nucleotide-excision repair\, DNA duplex unwinding; nucleotide-excision repair; transcription initiation from Pol II promoter; negative regulation of transcription from Pol II promoter\, mitotic; nucleotide excision repair factor 3 complex; transcription factor TFIIH complex; 05 03 04 ### CLUSTER 158 ### 14 Cell fate YOR215C WTM2 regulation of meiosis; nucleus; 04 RHO4 establishment of cell polarity (sensu Saccharomyces); actin filament organization; small GTPase mediated signal transduction; intracellular; 14 BEM4 establishment of cell polarity (sensu Saccharomyces); Rho protein signal transduction; actin cytoskeleton organization and biogenesis; 14 13 01 WTM1 regulation of meiosis; nucleus; 04 WSC2 cell wall organization and biogenesis; Rho protein signal transduction; response to heat; actin cytoskeleton organization and biogenesis; membrane fraction; cytoplasm; 01 RHO2 establishment of cell polarity (sensu Saccharomyces); actin filament organization; microtubule-based process; cell wall organization and biogenesis; small GTPase mediated signal transduction; intracellular; 10 14 01 BNI1 mitotic spindle orientation; establishment of cell polarity (sensu Saccharomyces); response to osmotic stress; actin filament organization; bud growth; polar budding; Rho protein signal transduction; mRNA localization\, intracellular; actin nucleation; incipient bud site; polarisome; actin cap (sensu Saccharomyces); actin filament; bud tip; bud neck; shmoo tip; 03 14 ROM2 establishment of cell polarity (sensu Saccharomyces); actin filament organization; cell wall organization and biogenesis; bud growth; small GTPase mediated signal transduction; bud tip; 01 14 GSC2 beta-1\,3 glucan biosynthesis; cell wall organization and biogenesis; actin cap (sensu Saccharomyces); 1\,3-beta-glucan synthase complex; 01 14 SAC7 small GTPase mediated signal transduction; cell cycle dependent actin filament reorganization; intracellular; 06 FKS1 beta-1\,3 glucan biosynthesis; cell wall organization and biogenesis; actin cap (sensu Saccharomyces); 1\,3-beta-glucan synthase complex; 01 LRG1 small GTPase mediated signal transduction; cell wall biosynthesis (sensu Fungi); 14 SKN7 transcription; response to osmotic stress; response to oxidative stress; nucleus; 14 10 03 11 04 ### CLUSTER 159 ### 05 Protein synthesis RSM7 protein biosynthesis; mitochondrial small ribosomal subunit; 05 TOM6 mitochondrial translocation; mitochondrial outer membrane translocase complex; 08 06 HOS4 histone deacetylation; negative regulation of meiosis; histone deacetylase complex; MRPL23 ribosomal large subunit assembly and maintenance; protein biosynthesis; mitochondrial large ribosomal subunit; 05 MRPS16 protein biosynthesis; mitochondrial small ribosomal subunit; 05 GPD2 glycerol metabolism; cytosol; 01 DIA2 invasive growth; DFR1 folic acid and derivative metabolism; cytosol; 01 YKL137W TAD2 tRNA modification; 04 MRP1 protein biosynthesis; mitochondrial small ribosomal subunit; 05 EDC2 deadenylation-dependent decapping; 04 MSY1 amino acid activation; mitochondrion; 05 RSM26 protein biosynthesis; mitochondrial small ribosomal subunit; 05 HRD1 ER-associated protein catabolism; endoplasmic reticulum membrane; 06 YCF1 cadmium ion transport; arsenite transport; bilirubin transport; response to mercury ion; vacuolar membrane; 11 08 MRPL33 protein biosynthesis; mitochondrial large ribosomal subunit; 05 ### CLUSTER 160 ### 00 Not clear SCS7 fatty acid metabolism; endoplasmic reticulum; 01 YGR102C ELA1 RNA elongation from Pol II promoter; transcription elongation factor complex; ### CLUSTER 161 ### 05 Protein synthesis YMR295C YNR036C 05 RSM19 protein biosynthesis; mitochondrial small ribosomal subunit; 05 MRPL10 protein biosynthesis; mitochondrial large ribosomal subunit; 05 ACP1 fatty acid biosynthesis; mitochondrion; 01 YMR157C SWS2 cytoplasm; mitochondrion; 05 PUS6 pseudouridine synthesis; tRNA modification; cytoplasm; mitochondrion; 04 MRPL19 protein biosynthesis; mitochondrial large ribosomal subunit; 05 YDR134C cell wall (sensu Fungi); ### CLUSTER 162 ### 05 Protein synthesis MRPL4 protein biosynthesis; mitochondrial large ribosomal subunit; 05 MRPL3 protein biosynthesis; mitochondrial large ribosomal subunit; 05 YKR065C ### CLUSTER 163 ### 05 Protein synthesis MRPL9 ribosomal large subunit assembly and maintenance; protein biosynthesis; mitochondrial large ribosomal subunit; 05 MRPL16 protein biosynthesis; mitochondrial large ribosomal subunit; 05 ### CLUSTER 164 ### 05 Protein synthesis APT2 01 RML2 protein biosynthesis; fatty acid metabolism; mitochondrial large ribosomal subunit; 05 MRPL49 protein biosynthesis; mitochondrial large ribosomal subunit; 05 PET191 cytochrome c oxidase biogenesis; mitochondrial inner membrane; 06 02 MRPL8 mitochondrial genome maintenance; protein biosynthesis; mitochondrial large ribosomal subunit; 05 MRPL13 protein biosynthesis; mitochondrial large ribosomal subunit; 05 CYT2 cytochrome c-heme linkage; mitochondrial intermembrane space; MRPL7 protein biosynthesis; mitochondrial large ribosomal subunit; 05 MRPL1 protein biosynthesis; aerobic respiration; mitochondrial large ribosomal subunit; 05 MRPL6 protein biosynthesis; mitochondrial large ribosomal subunit; 05 MRPL15 protein biosynthesis; mitochondrial large ribosomal subunit; 05 IMG2 protein biosynthesis; mitochondrial large ribosomal subunit; 05 YGL068W 05 MRPL32 protein biosynthesis; mitochondrial large ribosomal subunit; 05 RSM18 protein biosynthesis; mitochondrial small ribosomal subunit; 05 SHY1 aerobic respiration; mitochondrial inner membrane; 02 PFD1 protein folding; cytoskeleton organization and biogenesis; prefoldin complex; 06 MTM1 transport; manganese ion transport; mitochondrion; mitochondrial inner membrane; 08 FMC1 protein complex assembly; mitochondrion; 01 MRPL31 protein biosynthesis; mitochondrial large ribosomal subunit; 05 PCM1 N-acetylglucosamine biosynthesis; cytoplasm; 01 YHR049W YCG1 mitotic chromosome condensation; nuclear condensin complex; 03 YKR074W cytoplasm; YIL064W MEF1 translational elongation; mitochondrion; 05 MRS1 Group I intron splicing; mitochondrion; 04 YGL220W PMP3 cation transport; plasma membrane; MST1 threonyl-tRNA aminoacylation; mitochondrion; 05 ISC10 sporulation; 03 GLG1 glycogen biosynthesis; 02 GCV3 one-carbon compound metabolism; mitochondrion; 01 YJL083W PHB1 replicative cell aging; proteolysis and peptidolysis; mitochondrion; mitochondrial inner membrane; 03 MRPS35 protein biosynthesis; aerobic respiration; mitochondrial small ribosomal subunit; 05 MRPL38 protein biosynthesis; mitochondrial large ribosomal subunit; 05 COX17 cytochrome c oxidase biogenesis; intracellular copper ion transport; mitochondrial intermembrane space; cytosol; 13 06 02 AYR1 phosphatidic acid biosynthesis; cytoplasm; endoplasmic reticulum; lipid particle; 14 01 ATP14 ATP synthesis coupled proton transport; proton-transporting ATP synthase complex\, coupling factor F(o) (sensu Eukarya); 13 08 02 ### CLUSTER 165 ### 00 Not clear YLR193C ECM19 cell wall organization and biogenesis; ### CLUSTER 166 ### 00 Not clear RNH203 ATX1 copper ion transport; high affinity iron ion transport; response to oxidative stress; cytosol; 13 11 ### CLUSTER 167 ### 05 Protein synthesis MRPL35 protein biosynthesis; mitochondrial large ribosomal subunit; 05 IES5 ### CLUSTER 168 ### 05 Protein synthesis MRPL11 protein biosynthesis; mitochondrial large ribosomal subunit; 05 IMG1 protein biosynthesis; mitochondrial ribosome; 02 05 ### CLUSTER 169 ### 05 Protein synthesis MRPL36 protein biosynthesis; mitochondrial large ribosomal subunit; 05 MRPL27 protein biosynthesis; mitochondrial large ribosomal subunit; 05 YBR262C ### CLUSTER 170 ### 05 Protein synthesis MRPL24 protein biosynthesis; mitochondrial large ribosomal subunit; 05 MRP7 protein biosynthesis; mitochondrial large ribosomal subunit; 05 YML025C 05 ### CLUSTER 171 ### 11 Cell rescue/Defense YER077C CUP1-1 response to copper ion; cytosol; 11 CUP1-2 response to copper ion; cytosol; 11 ### CLUSTER 172 ### 03 Cell cycle & DNA processing YGL226W 02 YDR332W CIS1 regulation of CDK activity; 03 SPO7 nuclear organization and biogenesis; meiosis; sporulation (sensu Saccharomyces); integral to membrane; nuclear envelope-endoplasmic reticulum network; 14 03 YGR206W ECM34 cell wall organization and biogenesis; NEM1 nuclear organization and biogenesis; sporulation (sensu Saccharomyces); integral to membrane; nuclear envelope-endoplasmic reticulum network; 14 03 ### CLUSTER 173 ### 00 Not clear YDR459C MATALPHA2 regulation of transcription from Pol II promoter; regulation of transcription\, mating-type specific; donor preference; nucleus; 14 04 ### CLUSTER 174 ### 00 Not clear UGO1 transport; mitochondrial fusion; mitochondrial outer membrane; CPD1 DNA metabolism; meiosis; 03 YIL174W YIL157C ### CLUSTER 175 ### 06 Protein fate MPD1 protein folding; 06 DID2 protein-vacuolar targeting; cytoplasm; 06 08 ZRT2 low-affinity zinc ion transport; plasma membrane; 13 YOR086C ### CLUSTER 176 ### 08 Cellular transport SSO2 Golgi to plasma membrane transport; nonselective vesicle fusion; cytoplasm; endoplasmic reticulum; integral to plasma membrane; 08 14 SPO20 nonselective vesicle fusion; spore wall assembly (sensu Saccharomyces); prospore membrane; 14 08 SEC2 exocytosis; cytosol; cytoplasmic vesicle; 08 SEC9 Golgi to plasma membrane transport; nonselective vesicle fusion; membrane; 08 14 ### CLUSTER 177 ### 08 Cellular transport EXO84 establishment of cell polarity (sensu Saccharomyces); nuclear mRNA splicing\, via spliceosome; cytokinesis; Golgi to plasma membrane transport; nonselective vesicle docking; nonselective vesicle fusion; polar budding; actin cap (sensu Saccharomyces); exocyst; 08 14 SEC15 establishment of cell polarity (sensu Saccharomyces); cytokinesis; Golgi to plasma membrane transport; nonselective vesicle docking; nonselective vesicle fusion; polar budding; actin cap (sensu Saccharomyces); exocyst; 08 14 SEC6 establishment of cell polarity (sensu Saccharomyces); cytokinesis; Golgi to plasma membrane transport; endocytosis; nonselective vesicle docking; nonselective vesicle fusion; polar budding; actin cap (sensu Saccharomyces); exocyst; 08 SEC10 establishment of cell polarity (sensu Saccharomyces); cytokinesis; Golgi to plasma membrane transport; nonselective vesicle docking; nonselective vesicle fusion; polar budding; actin cap (sensu Saccharomyces); exocyst; 08 SEC3 establishment of cell polarity (sensu Saccharomyces); cytokinesis; Golgi to plasma membrane transport; nonselective vesicle docking; nonselective vesicle fusion; polar budding; actin cap (sensu Saccharomyces); exocyst; 08 14 ### CLUSTER 178 ### 08 Cellular transport SEC5 establishment of cell polarity (sensu Saccharomyces); cytokinesis; Golgi to plasma membrane transport; nonselective vesicle docking; nonselective vesicle fusion; polar budding; actin cap (sensu Saccharomyces); exocyst; 08 SEC1 exocytosis; nonselective vesicle docking; nonselective vesicle fusion; actin cap (sensu Saccharomyces); 08 SEC4 cytokinesis; exocytosis; Golgi to plasma membrane transport; nonselective vesicle fusion; polar budding; small GTPase mediated signal transduction; actin cap (sensu Saccharomyces); transport vesicle; 14 08 ### CLUSTER 179 ### 00 Not clear VPS72 protein-vacuolar targeting; cytoplasm; SRO77 exocytosis; Golgi to plasma membrane transport; plasma membrane; 14 08 ### CLUSTER 180 ### 06 Protein fate VPS8 late endosome to vacuole transport; membrane fraction; 06 08 VPS41 high affinity iron ion transport; vacuole organization and biogenesis; protein transport; homotypic vacuole fusion (non-autophagic); vacuole (sensu Fungi); vacuolar membrane; 06 VPS33 Golgi to endosome transport; homotypic vacuole fusion (non-autophagic); late endosome to vacuole transport; vacuolar membrane (sensu Fungi); cytosol; 08 06 PEP3 Golgi to endosome transport; nonselective vesicle docking; homotypic vacuole fusion (non-autophagic); late endosome to vacuole transport; extrinsic to vacuolar membrane; vacuolar membrane (sensu Fungi); 08 06 YDR109C MCH2 transport; membrane; YNR047W response to pheromone; ### CLUSTER 181 ### 00 Not clear VAM6 vacuole organization and biogenesis; homotypic vacuole fusion (non-autophagic); vacuole (sensu Fungi); vacuolar membrane; 06 AAP1 ATP synthesis coupled proton transport; proton-transporting ATP synthase complex\, coupling factor F(o) (sensu Eukarya); 13 02 08 ### CLUSTER 182 ### 08 Cellular transport VPS45 protein complex assembly; Golgi to vacuole transport; vacuole organization and biogenesis; osmoregulation; Golgi membrane; cytosol; extrinsic to membrane; 14 08 06 TLG1 nonselective vesicle fusion; Golgi trans cisterna; early endosome; Golgi trans face; 06 08 COG7 intra-Golgi transport; Golgi transport complex; 08 ### CLUSTER 183 ### 08 Cellular transport VTI1 intra-Golgi transport; Golgi to vacuole transport; nonselective vesicle fusion; endosome to lysosome transport; integral to Golgi membrane; 06 08 APL6 Golgi to vacuole transport; AP-3 adaptor complex; 08 SEC17 ER to Golgi transport; peripheral to membrane of membrane fraction; 08 NYV1 nonselective vesicle fusion; vacuolar membrane; 06 YKT6 intra-Golgi transport; nonselective vesicle fusion; membrane; 06 08 VAM7 Golgi to vacuole transport; nonselective vesicle fusion; vacuolar membrane (sensu Fungi); 08 PEP1 protein-vacuolar targeting; vacuolar transport; Golgi apparatus; 08 06 ### CLUSTER 184 ### 00 Not clear RIB5 vitamin B2 biosynthesis; soluble fraction; 01 PMC1 calcium ion transport; calcium ion homeostasis; vacuolar membrane (sensu Fungi); 13 08 ### CLUSTER 185 ### 00 Not clear NCP1 ergosterol biosynthesis; microsome; 01 11 MF(ALPHA)2 response to pheromone during conjugation with cellular fusion; extracellular; 14 ### CLUSTER 186 ### 08 Cellular transport MRPS17 protein biosynthesis; aerobic respiration; mitochondrial small ribosomal subunit; 05 SEC20 retrograde (Golgi to ER) transport; nonselective vesicle fusion; endoplasmic reticulum; endoplasmic reticulum membrane; 08 06 YPT6 intracellular protein transport; retrograde (endosome to Golgi) transport; Golgi apparatus; 08 VPS63 ### CLUSTER 187 ### 08 Cellular transport SFT1 intra-Golgi transport; Golgi membrane; 08 GOS1 intra-Golgi transport; nonselective vesicle fusion; integral to membrane; 06 08 COG1 retrograde (vesicle recycling within Golgi) transport; intra-Golgi transport; Golgi transport complex; 08 COG3 retrograde (vesicle recycling within Golgi) transport; ER to Golgi transport; intra-Golgi transport; peripheral to membrane of membrane fraction; soluble fraction; Golgi transport complex; 08 ### CLUSTER 188 ### 08 Cellular transport SED5 ER to Golgi transport; retrograde (Golgi to ER) transport; intra-Golgi transport; nonselective vesicle fusion; Golgi cis-face; 08 SLY1 ER to Golgi transport; endoplasmic reticulum; Golgi apparatus; ER-Golgi transport vesicle; 08 SEC28 ER to Golgi transport; nonselective vesicle coating; COPI vesicle coat; 08 06 SEC27 ER to Golgi transport; retrograde (Golgi to ER) transport; COPI vesicle coat; 08 BET1 ER to Golgi transport; retrograde (Golgi to ER) transport; endoplasmic reticulum membrane; COPII-coated vesicle; 08 ARF1 ER to Golgi transport; intra-Golgi transport; Golgi vesicle; cytosol; 06 08 SEC26 ER to Golgi transport; COPI vesicle coat; coated vesicle; 08 COP1 ER to Golgi transport; retrograde (Golgi to ER) transport; COPI vesicle coat; 08 RET2 ER to Golgi transport; retrograde (Golgi to ER) transport; COPI vesicle coat; 08 SEC22 ER to Golgi transport; retrograde (Golgi to ER) transport; intra-Golgi transport; nonselective vesicle fusion; endoplasmic reticulum; Golgi apparatus; integral to membrane; 08 BOS1 ER to Golgi transport; endoplasmic reticulum membrane; 08 ### CLUSTER 189 ### 08 Cellular transport SFB3 ER to Golgi transport; peripheral to membrane of membrane fraction; endoplasmic reticulum; COPII vesicle coat; SAR1 ER to Golgi transport; COPII vesicle coat; 08 SEC31 ER to Golgi transport; COPII vesicle coat; 08 EMP24 ER to Golgi transport; vesicle organization and biogenesis; endoplasmic reticulum; integral to membrane; COPII-coated vesicle; 08 SFB2 ER to Golgi transport; COPII vesicle coat; ERV25 ER to Golgi transport; COPII-coated vesicle; 08 SEC13 ER to Golgi transport; nonselective vesicle assembly; ER-associated protein catabolism; nuclear pore; cytoplasm; extrinsic to plasma membrane; COPII vesicle coat; 08 SEC12 ER to Golgi transport; ER-associated protein catabolism; integral to membrane of membrane fraction; integral to endoplasmic reticulum membrane; 08 SEC16 autophagy; vesicle-mediated transport; endoplasmic reticulum membrane; COPII vesicle coat; 06 08 MF(ALPHA)1 response to pheromone during conjugation with cellular fusion; extracellular; 14 SEC62 SRP-dependent cotranslational membrane targeting\, translocation; endoplasmic reticulum membrane; 06 08 EUG1 protein folding; endoplasmic reticulum; 06 SEC24 ER to Golgi transport; autophagy; COPII vesicle coat; 08 ### CLUSTER 190 ### 00 Not clear ORM1 response to unfolded protein; YIP5 membrane; YIP4 membrane; YPT31 exocytosis; vesicle-mediated transport; Golgi apparatus; 08 YPT1 protein complex assembly; ER to Golgi transport; Golgi membrane; endoplasmic reticulum membrane; 08 YPT10 Golgi organization and biogenesis; 08 TVP23 ### CLUSTER 191 ### 08 Cellular transport YPT32 exocytosis; vesicle-mediated transport; Golgi apparatus; 08 YGR223C VPS34 vacuole inheritance; protein amino acid phosphorylation; protein-vacuolar targeting; vacuolar transport; membrane fraction; 01 10 08 YIP1 vesicle-mediated transport; Golgi apparatus; membrane; 08 14 YPT7 vacuole inheritance; Golgi to vacuole transport; vesicle-mediated transport; vacuole; 08 YPT53 protein-vacuolar targeting; endocytosis; late endosome; 08 06 YDR018C phospholipid biosynthesis; ### CLUSTER 192 ### 00 Not clear MSS4 actin cytoskeleton organization and biogenesis; actin cable assembly; plasma membrane; 14 01 10 BPH1 response to pH; 08 ### CLUSTER 193 ### 08 Cellular transport SAC2 08 LUV1 08 GYP6 intracellular protein transport; 08 VPS53 Golgi to vacuole transport; GARP complex; cytoplasm; Golgi apparatus; 08 VPS67 SGM1 SYS1 Golgi to endosome transport; vesicle organization and biogenesis; integral to Golgi membrane; 08 MDR1 soluble fraction; 04 11 ### CLUSTER 194 ### 06 Protein fate APG16 06 APG12 06 ### CLUSTER 195 ### 03 Cell cycle & DNA processing RHB1 L-arginine transport; L-lysine transport; extrinsic to plasma membrane; 10 AGE1 ER to Golgi transport; intra-Golgi transport; GCS1 ER to Golgi transport; retrograde (Golgi to ER) transport; cell cycle dependent actin filament reorganization; ER-Golgi intermediate compartment; cytoskeleton; 03 08 GLO3 ER to Golgi transport; retrograde (Golgi to ER) transport; ER-Golgi intermediate compartment; 03 04 ### CLUSTER 196 ### 03 Cell cycle & DNA processing RSR1 bud site selection; axial budding; polar budding; small GTPase mediated signal transduction; plasma membrane; bud; 14 GTS1 regulation of cell cycle; cellular morphogenesis; chronological cell aging; multidrug transport; sporulation (sensu Saccharomyces); ultradian rhythm; nucleus; cytoplasm; 03 11 14 04 SPS18 sporulation; 14 03 04 RAS2 replicative cell aging; pseudohyphal growth; sporulation (sensu Saccharomyces); adenylate cyclase activation; RAS protein signal transduction; plasma membrane; 01 13 10 14 11 03 AGE2 ER to Golgi transport; intra-Golgi transport; CDC25 regulation of cell cycle; start control point of mitotic cell cycle; RAS protein signal transduction; cytoplasm; plasma membrane; 01 03 13 STE6 peptide pheromone export; integral to plasma membrane; shmoo tip; 14 08 YMR323W cytoplasm; 02 01 YLR445W SDC25 RAS protein signal transduction; 03 IRA1 sporulation (sensu Saccharomyces); RAS protein signal transduction; membrane; 13 CYR1 regulation of cell cycle; meiosis; G-protein signaling\, coupled to cAMP nucleotide second messenger; RAS protein signal transduction; plasma membrane; 01 03 13 10 14 ### CLUSTER 197 ### 03 Cell cycle & DNA processing YDL218W cytoplasm; CDC2 leading strand elongation; lagging strand elongation; mutagenesis; base-excision repair; nucleotide-excision repair; mismatch repair; postreplication repair; delta DNA polymerase complex; 03 ### CLUSTER 198 ### 06 Protein fate SCJ1 protein folding; endoplasmic reticulum lumen; 06 KAR2 karyogamy during conjugation with cellular fusion; SRP-dependent cotranslational membrane targeting\, translocation; response to unfolded protein; endoplasmic reticulum lumen; 03 06 08 SEC72 SRP-dependent cotranslational membrane targeting\, translocation; endoplasmic reticulum membrane; 06 08 SEC61 SRP-dependent cotranslational membrane targeting\, translocation; translocon; endoplasmic reticulum lumen; endoplasmic reticulum membrane; 08 06 SEC66 SRP-dependent cotranslational membrane targeting\, translocation; endoplasmic reticulum membrane; 08 06 YOR223W NPL6 protein-nucleus import; nucleus; 06 ### CLUSTER 199 ### 00 Not clear HSP60 protein folding; mitochondrial translocation; mitochondrion; 11 06 HCH1 protein folding; response to stress; YMR124W cytoplasm; ### CLUSTER 200 ### 06 Protein fate CTF13 centromere/kinetochore complex maturation; condensed nuclear chromosome kinetochore; 03 STI1 protein folding; cytoplasm; 11 14 HSP10 protein folding; mitochondrial matrix; 06 STE11 signal transduction during conjugation with cellular fusion; protein amino acid phosphorylation; pseudohyphal growth; cytoplasm; 14 13 YOR256C CPR7 response to stress; cytosol; 14 04 06 CPR6 protein folding; cytoplasm; 06 04 SBA1 protein folding; nucleus; cytoplasm; 14 06 AHA1 protein folding; response to stress; cytoplasm; 06 11 PEP12 Golgi to vacuole transport; endosome; Golgi apparatus; 08 06 SSA3 protein folding; SRP-dependent cotranslational membrane targeting\, translocation; protein-mitochondrial targeting; response to stress; cytosol; 11 SSA1 protein-nucleus import\, translocation; protein folding; SRP-dependent cotranslational membrane targeting\, translocation; vacuolar membrane (sensu Fungi); nucleus; cytoplasm; cell wall (sensu Fungi); 06 11 08 TAH11 DNA replication licensing; nucleus; cytoplasm; 03 SSA4 protein folding; SRP-dependent cotranslational membrane targeting\, translocation; response to stress; nucleus; cytoplasm; 11 SSA2 protein folding; SRP-dependent cotranslational membrane targeting\, translocation; vacuolar membrane (sensu Fungi); cytoplasm; cell wall (sensu Fungi); 06 08 HSP104 protein folding; response to stress; nucleus; cytoplasm; 06 11 SIS1 translational initiation; cytosolic small ribosomal subunit (sensu Eukarya); 05 03 HSC82 protein folding; response to stress; 11 CIN1 post-chaperonin tubulin folding pathway; beta-tubulin folding; microtubule; 03 YDJ1 protein-mitochondrial targeting; cytosol; 08 03 06 11 CDC37 regulation of cell cycle; spindle pole body duplication (sensu Saccharomyces); signal transduction; 03 06 ### CLUSTER 201 ### 06 Protein fate DJP1 peroxisome matrix protein import; cytosol; 08 06 CAJ1 06 YJL162C APA1 nucleotide metabolism; 01 TAT1 amino acid transport; plasma membrane; 01 08 SSB1 protein biosynthesis; soluble fraction; polysome; 05 XDJ1 06 HLJ1 06 ### CLUSTER 202 ### 08 Cellular transport TIM9 mitochondrial translocation; mitochondrial intermembrane space; mitochondrial intermembrane space protein transporter complex; 06 08 PET9 ATP/ADP exchange; mitochondrial inner membrane; 01 08 TIM22 mitochondrial translocation; mitochondrial inner membrane protein insertion complex; 06 08 MRS5 mitochondrial translocation; mitochondrial intermembrane space; mitochondrial inner membrane protein insertion complex; 06 08 ### CLUSTER 203 ### 00 Not clear TIM54 mitochondrial translocation; mitochondrial inner membrane protein insertion complex; 06 08 SPO14 phospholipid metabolism; exocytosis; sporulation (sensu Fungi); prospore membrane; endosome; 14 03 01 ### CLUSTER 204 ### 00 Not clear TIM8 mitochondrial translocation; mitochondrial intermembrane space protein transporter complex; 08 06 DNM1 mitochondrial fission; mitochondrial outer membrane; ### CLUSTER 205 ### 00 Not clear MAS6 mitochondrial translocation; mitochondrion; mitochondrial inner membrane pre-sequence translocase complex; 08 06 CYB2 electron transport; mitochondrial intermembrane space; 01 02 ### CLUSTER 206 ### 06 Protein fate SSC1 protein folding; mitochondrial translocation; mitochondrion; mitochondrial inner membrane; 06 08 11 TIM13 mitochondrial translocation; mitochondrial intermembrane space; mitochondrial intermembrane space protein transporter complex; 06 TIM44 mitochondrial translocation; mitochondrial matrix; 06 08 TIM17 mitochondrial translocation; mitochondrial inner membrane pre-sequence translocase complex; 06 08 MRS11 mitochondrial translocation; mitochondrial intermembrane space; mitochondrial intermembrane space protein transporter complex; 06 08 ### CLUSTER 207 ### 06 Protein fate TOM20 mitochondrial translocation; mitochondrial outer membrane translocase complex; 06 08 TOM70 mitochondrial translocation; mitochondrial outer membrane translocase complex; 06 08 TOM7 mitochondrial translocation; mitochondrial outer membrane translocase complex; 06 08 TOM40 mitochondrial translocation; mitochondrion; mitochondrial outer membrane translocase complex; 08 06 YDR307W 01 06 YJR115W ### CLUSTER 208 ### 01 Metabolism YDL099W MET14 sulfate assimilation; methionine metabolism; cell; 01 ### CLUSTER 209 ### 04 Transcription/RNA processing/RNA transport NUP116 tRNA splicing; mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; protein-nucleus import; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; nuclear pore; 08 04 KAP95 protein-nucleus import; nuclear pore; cytoplasm; 08 06 RRP7 ribosomal small subunit assembly and maintenance; 35S primary transcript processing; 04 05 06 YRA1 mRNA-nucleus export; transcription export complex; 04 YGR081C LYS12 lysine biosynthesis; cytoplasm; mitochondrion; 01 GON7 response to dessication; PDA1 pyruvate metabolism; mitochondrion; pyruvate dehydrogenase complex; 01 02 DAM1 mitotic spindle assembly (sensu Saccharomyces); condensed nuclear chromosome kinetochore; spindle; kinetochore microtubule; 03 KTI12 cell growth and/or maintenance; carbon utilization; DNA-directed RNA polymerase II\, holoenzyme; 11 NDC1 RNA-nucleus export; protein-nucleus import; microtubule nucleation; spindle pole body duplication (sensu Saccharomyces); nuclear pore; spindle pole body; 03 POM152 mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; nuclear pore; 08 MDS3 sporulation; cytoplasm; 14 KIN2 membrane fraction; CSM3 meiotic chromosome segregation; YML059C YAL061W 01 02 ACA1 transcription initiation from Pol II promoter; nucleus; 04 YAP1 transcription; response to oxidative stress; response to drug; nucleus; cytoplasm; 04 11 NUP53 protein-nucleus import\, docking; mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; nuclear pore; 08 GFA1 cell wall chitin biosynthesis; 01 14 YIG1 14 SPO12 mitotic cell cycle; regulation of exit from mitosis; meiosis I; nucleus; nucleolus; 03 14 ### CLUSTER 210 ### 01 Metabolism SOR1 fructose metabolism; mannose metabolism; 01 NMA2 nicotinamide adenine dinucleotide metabolism; nucleus; 01 UFD4 protein polyubiquitination; protein monoubiquitination; cytoplasm; 06 ### CLUSTER 211 ### 01 Metabolism THI4 DNA repair; thiamin biosynthesis; mitochondrion; 01 03 SHE2 mRNA localization\, intracellular; cytoplasm; 14 CSE1 protein-nucleus export; nuclear membrane; 08 06 XPT1 purine nucleotide biosynthesis; 01 STS1 ubiquitin-dependent protein catabolism; chromosome segregation; nucleus; 04 08 YGR024C GLE2 mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; protein-nucleus import; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear membrane organization and biogenesis; nuclear pore organization and biogenesis; nuclear pore; 04 08 TVP15 PHO13 protein amino acid dephosphorylation; histone dephosphorylation; 01 YER010C YBR137W cytoplasm; HPA3 histone acetylation; 03 06 YCR076C NIF3 04 ### CLUSTER 212 ### 01 Metabolism RRF1 protein biosynthesis; mitochondrion; 05 BIT61 YJR056C YJL218W 01 SOR2 01 MNS1 N-linked glycosylation; endoplasmic reticulum; 01 06 MBB1 ### CLUSTER 213 ### 01 Metabolism GLE1 poly(A)+ mRNA-nucleus export; nuclear pore; 08 04 MET13 sulfur amino acid biosynthesis; protein biosynthesis; methionine metabolism; cell; mitochondrial large ribosomal subunit; 01 05 GPI8 attachment of GPI anchor to protein; integral to endoplasmic reticulum membrane; 06 01 ### CLUSTER 214 ### 08 Cellular transport SAC3 mRNA-nucleus export; protein-nucleus export; mitosis; actin filament-based process; RNA nuclear export complex; 01 04 SXM1 mRNA-nucleus export; nucleocytoplasmic transport; nucleus; 04 08 NUP170 protein-nucleus import\, docking; mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; chromosome segregation; nuclear pore; 08 03 NUP159 ribosome-nucleus export; mRNA-nucleus export; rRNA-nucleus export; nuclear pore organization and biogenesis; nuclear pore; 08 NSP1 ribosomal large subunit-nucleus export; RNA-nucleus export; mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; protein-nucleus import; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; nuclear pore; 04 08 SPO74 sporulation (sensu Saccharomyces); spindle pole body; NUP60 protein-nucleus import\, docking; nucleocytoplasmic transport; nuclear pore; 08 NUP2 mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; nuclear pore; 08 NUP100 mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; nuclear pore; 04 08 IES3 YLR016C NUP133 mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; nuclear pore; 14 08 04 PNP1 purine nucleoside catabolism; 01 NUP82 mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; nuclear pore; 08 04 MSN5 protein-nucleus export; nucleus; 14 08 NUP84 mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear membrane organization and biogenesis; nuclear pore organization and biogenesis; nuclear pore; 14 08 NUP145 tRNA splicing; mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; protein-nucleus import; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; nuclear pore; 04 08 NUP85 mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear membrane organization and biogenesis; nuclear pore organization and biogenesis; nuclear pore; 04 08 14 NUP120 mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; nuclear pore; 04 08 SEH1 mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; nuclear pore; 08 14 NUP57 mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; protein-nucleus import; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; nuclear pore; 08 NUP49 ribosomal large subunit-nucleus export; tRNA splicing; mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; protein-nucleus import; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; nuclear membrane; nuclear pore; 04 08 NUP42 mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; nuclear pore; 04 08 ### CLUSTER 215 ### 08 Cellular transport PIM1 proteolysis and peptidolysis; response to heat; mitochondrial matrix; 06 04 YRB2 mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; nuclear pore; 08 MOG1 protein-nucleus import; nucleus; 06 08 YRB1 G1/S transition of mitotic cell cycle; RNA-nucleus export; ubiquitin-dependent protein catabolism; protein-nucleus import; nucleus; cytoplasm; 04 08 SRM1 ribosome-nucleus export; rRNA-nucleus export; nucleus; 14 04 08 NTF2 protein-nucleus import; nucleocytoplasmic transport; nuclear membrane; 08 ### CLUSTER 216 ### 11 Cell rescue/Defense YBP1 response to oxidative stress; GSH1 glutathione biosynthesis; response to cadmium ion; intracellular; 11 ### CLUSTER 217 ### 00 Not clear STO1 nuclear mRNA splicing\, via spliceosome; commitment complex; snRNA cap binding complex; 04 SRP1 nucleocytoplasmic transport; nucleus; cytoplasm; 06 08 ### CLUSTER 218 ### 04 Transcription/RNA processing/RNA transport RNA15 mRNA polyadenylation; mRNA cleavage; mRNA cleavage factor complex; 04 PCF11 transcription termination from Pol II promoter; mRNA polyadenylation; mRNA cleavage; mRNA cleavage factor complex; 04 ### CLUSTER 219 ### 04 Transcription/RNA processing/RNA transport AEP1 protein biosynthesis; 04 05 TCM10 protein complex assembly; mitochondrial inner membrane; NAB2 mRNA polyadenylation; poly(A)+ mRNA-nucleus export; nucleus; cytoplasm; 04 RNA14 mRNA polyadenylation; mRNA cleavage; nucleus; mitochondrion; mRNA cleavage factor complex; 04 NAM7 mRNA catabolism\, nonsense-mediated; mRNA catabolism; regulation of translational termination; cytoplasm; polysome; 05 01 KAP104 protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; cell cycle; cytosol; 08 ### CLUSTER 220 ### 11 Cell rescue/Defense TIR1 response to stress; cell wall (sensu Fungi); 11 VID27 NSR1 ribosomal small subunit assembly and maintenance; rRNA processing; nucleus; nucleolus; 11 04 ### CLUSTER 221 ### 00 Not clear MLP2 protein-nucleus import; nuclear membrane; nucleoplasm; 08 ASM4 protein-nucleus import\, docking; mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; nuclear pore; 03 ### CLUSTER 222 ### 00 Not clear ECM31 pantothenate biosynthesis; 01 YBL055C ISN1 ### CLUSTER 223 ### 00 Not clear PGI1 gluconeogenesis; glycolysis; pentose-phosphate shunt; cytosol; 02 01 BLM3 membrane; NUP157 mRNA-nucleus export; rRNA-nucleus export; snRNA-nucleus export; tRNA-nucleus export; NLS-bearing substrate-nucleus import; snRNP protein-nucleus import; mRNA-binding (hnRNP) protein-nucleus import; ribosomal protein-nucleus import; protein-nucleus export; nuclear pore organization and biogenesis; nuclear pore; 08 ### CLUSTER 224 ### 01 Metabolism UPF3 mRNA catabolism\, nonsense-mediated; mRNA catabolism; cytoplasm; polysome; 01 05 NMD2 mRNA catabolism\, nonsense-mediated; mRNA catabolism; cytoplasm; polysome; 01 05 ### CLUSTER 225 ### 01 Metabolism NMD5 protein-nucleus import; nucleus; cytoplasm; 01 NMD4 mRNA catabolism\, nonsense-mediated; 01 ### CLUSTER 226 ### 00 Not clear EDC3 EBS1 telomerase-dependent telomere maintenance; nucleus; 03 YMR132C YBR094W ### CLUSTER 227 ### 00 Not clear YMR184W GPT2 phospholipid biosynthesis; cytoplasm; endoplasmic reticulum; ### CLUSTER 228 ### 06 Protein fate PDR10 multidrug transport; plasma membrane; SNC2 Golgi to plasma membrane transport; endocytosis; nonselective vesicle fusion; transport vesicle; 08 06 OCT1 mitochondrial processing; iron ion homeostasis; mitochondrion; 06 13 SCD5 endocytosis; actin filament organization; protein secretion; peripheral to membrane of membrane fraction; actin cortical patch (sensu Saccharomyces); 08 06 MIP1 DNA dependent DNA replication; mitochondrion; 03 ### CLUSTER 229 ### 00 Not clear PPZ1 sodium ion homeostasis; nucleus; cytoplasm; 11 GLC7 cellular morphogenesis during vegetative growth; glycogen metabolism; regulation of carbohydrate metabolism; 35S primary transcript processing; mitotic spindle checkpoint; meiosis; response to heat; transcription termination from Pol II promoter\, poly(A) coupled; transcription termination from Pol II promoter\, poly(A) independent; protein phosphatase type 1 complex; nucleolus; mRNA cleavage and polyadenylation specificity factor complex; bud neck; 01 02 14 05 03 ### CLUSTER 230 ### 06 Protein fate YGL232W VMA22 glycogen metabolism; protein complex assembly; vacuolar acidification; endoplasmic reticulum membrane; 06 ### CLUSTER 231 ### 08 Cellular transport YJL206C 04 VPH1 polyphosphate metabolism; vacuolar acidification; hydrogen-transporting ATPase V0 domain; vacuole; 13 08 06 STV1 vacuolar acidification; hydrogen-transporting ATPase V0 domain; endosome; Golgi apparatus; 13 08 TFP1 intron homing; vacuolar acidification; protein metabolism; hydrogen-transporting ATPase V1 domain; vacuolar membrane (sensu Fungi); 13 08 06 VMA8 vacuolar acidification; hydrogen-transporting ATPase V1 domain; vacuolar membrane (sensu Fungi); 13 08 VMA7 vacuolar acidification; hydrogen-transporting ATPase V1 domain; vacuolar membrane (sensu Fungi); 13 08 VMA5 vacuolar acidification; hydrogen-transporting ATPase V1 domain; vacuolar membrane (sensu Fungi); 13 08 06 VMA10 glycogen metabolism; vacuolar acidification; hydrogen-transporting ATPase V1 domain; 13 08 VMA6 vacuolar transport; vacuolar acidification; hydrogen-transporting ATPase V0 domain; vacuolar membrane; 13 08 06 VMA21 protein complex assembly; endoplasmic reticulum; endoplasmic reticulum membrane; 06 RAV1 vacuolar acidification; hydrogen-transporting ATPase V1 domain; cytoplasm; 02 VMA2 vacuolar acidification; hydrogen-transporting ATPase V1 domain; cytoplasm; 08 13 ### CLUSTER 232 ### 01 Metabolism YBR184W CDS1 phosphatidylglycerol biosynthesis; phosphatidylserine metabolism; mitochondrion; endoplasmic reticulum; 01 ### CLUSTER 233 ### 00 Not clear YMR265C COX18 cytochrome c oxidase biogenesis; mitochondrial inner membrane; integral to membrane; 02 06 ### CLUSTER 234 ### 03 Cell cycle & DNA processing SYN8 transport; endosome; 08 06 GIP1 spore wall assembly (sensu Saccharomyces); protein phosphatase type 1 complex; prospore membrane; 03 14 04 GIP2 protein amino acid dephosphorylation; protein phosphatase type 1 complex; 01 02 FIN1 nucleus; spindle pole body; 03 ### CLUSTER 235 ### 01 Metabolism REG1 negative regulation of transcription from Pol II promoter; glycogen metabolism; regulation of carbohydrate metabolism; cell growth and/or maintenance; protein phosphatase type 1 complex; cytoplasm; 01 04 SNF1 glucose metabolism; regulation of carbohydrate metabolism; protein amino acid phosphorylation; cellular response to nitrogen starvation; cell adhesion; signal transduction; filamentous growth; vacuole (sensu Fungi); nucleus; cytoplasm; 11 01 SIP1 protein amino acid phosphorylation; signal transduction; vacuole; 01 SNF4 regulation of transcription from Pol II promoter; peroxisome organization and biogenesis; nucleus; cytoplasm; plasma membrane; 04 11 01 GAL83 protein amino acid phosphorylation; cell adhesion; signal transduction; filamentous growth; nucleus; 01 04 ### CLUSTER 236 ### 04 Transcription/RNA processing/RNA transport YER130C 04 NRG1 glucose metabolism; regulation of transcription from Pol II promoter; invasive growth; response to pH; nucleus; 01 04 ### CLUSTER 237 ### 04 Transcription/RNA processing/RNA transport TUP1 negative regulation of transcription; nucleus; 04 CYC8 negative regulation of transcription; nucleus; 04 ### CLUSTER 238 ### 01 Metabolism PSD2 phosphatidylcholine biosynthesis; Golgi membrane; vacuolar membrane (sensu Fungi); 01 YGP1 response to stress; response to nutrients; cell wall (sensu Fungi); 11 CSR1 cell wall organization and biogenesis; phospholipid transport; cytoplasm; microsome; cytosol; 01 HOG1 protein amino acid phosphorylation; hyperosmotic response; positive regulation of transcription from Pol II promoter; nucleus; cytoplasm; 01 11 13 ### CLUSTER 239 ### 01 Metabolism DIE2 N-linked glycosylation; dolichol-linked oligosaccharide biosynthesis; endoplasmic reticulum membrane; 01 BRE2 chromatin silencing at telomere; transcription; histone methylation; nuclear chromatin; ### CLUSTER 240 ### 00 Not clear SWD3 chromatin silencing at telomere; histone methylation; nuclear chromatin; SWD1 chromatin silencing at telomere; histone methylation; nuclear chromatin; 04 03 SHG1 histone methylation; SDC1 chromatin silencing at telomere; histone methylation; nuclear chromatin; SET1 chromatin silencing at telomere; histone methylation; nucleus; 14 03 ### CLUSTER 241 ### 00 Not clear POP8 rRNA processing; tRNA processing; ribonuclease MRP complex; nucleolar ribonuclease P complex; 04 ATS1 microtubule-based process; 03 ### CLUSTER 242 ### 04 Transcription/RNA processing/RNA transport YLR408C SSU72 35S primary transcript processing; transcription initiation from Pol II promoter; transcription termination from Pol II promoter; snoRNA transcription; transcription termination from Pol II promoter\, poly(A) coupled; transcription termination from Pol II promoter\, poly(A) independent; nucleus; mRNA cleavage and polyadenylation specificity factor complex; 04 ### CLUSTER 243 ### 00 Not clear YGL159W PFS2 mRNA polyadenylation; mRNA cleavage; mRNA cleavage and polyadenylation specificity factor complex; 04 MPD2 protein folding; endoplasmic reticulum; 06 ### CLUSTER 244